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TFIID or not TFIID, a continuing transcriptional SAGA
Eukaryotic protein‐coding genes are typically classified into two groups: those with expression regulated by specific signals versus the relatively constant “housekeeping” genes. Although these differences are associated with alternative modes of RNA polymerase II (RNAP II) pre‐initiation complex (P...
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| Published in: | The EMBO journal 2017-02, Vol.36 (3), p.248-249 |
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| container_title | The EMBO journal |
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| creator | Kubik, Slawomir Bruzzone, Maria Jessica Shore, David |
| description | Eukaryotic protein‐coding genes are typically classified into two groups: those with expression regulated by specific signals versus the relatively constant “housekeeping” genes. Although these differences are associated with alternative modes of RNA polymerase II (RNAP II) pre‐initiation complex (PIC) assembly, a role for gene‐specific activators in controlling “regulatability” has been difficult to rule out. To address this question, de Jonge
et al
(
2017
) studied a group of genes controlled by a common activator but dependent on either TFIID or SAGA and found that the magnitude of regulation strongly correlates with the mechanism of PIC assembly.
Graphical Abstract
Alternative modes of transcriptional pre‐initiation complex assembly rather than gene‐specific activators differentiate housekeeping gene expression from regulated gene expression. |
| doi_str_mv | 10.15252/embj.201696152 |
| format | article |
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et al
(
2017
) studied a group of genes controlled by a common activator but dependent on either TFIID or SAGA and found that the magnitude of regulation strongly correlates with the mechanism of PIC assembly.
Graphical Abstract
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et al
(
2017
) studied a group of genes controlled by a common activator but dependent on either TFIID or SAGA and found that the magnitude of regulation strongly correlates with the mechanism of PIC assembly.
Graphical Abstract
Alternative modes of transcriptional pre‐initiation complex assembly rather than gene‐specific activators differentiate housekeeping gene expression from regulated gene expression.</description><subject>EMBO09</subject><subject>EMBO44</subject><subject>Eukaryotes</subject><subject>Gene expression</subject><subject>Humans</subject><subject>News & Views</subject><subject>Proteins</subject><subject>RNA polymerase</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae Proteins - genetics</subject><subject>TATA-Binding Protein Associated Factors - genetics</subject><subject>Transcription Factor TFIID - genetics</subject><subject>Transcription, Genetic</subject><subject>Views</subject><issn>0261-4189</issn><issn>1460-2075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkc1LwzAAxYMoOj_O3qTgxYPVJM1H40GYuulE8aCeQ9qmM6NLZtIq_vdGp2MK4ikk-b3HezwAdhE8QhRTfKynxeQIQ8QEiw8roIcIgymGnK6CHsQMpQTlYgNshjCBENKco3WwgXPIBIe8B-jDcDS6SJxPrGuTz8thopLS2dbYzthx0nplQ-nNrDXOqia571_2t8FarZqgd77OLfA4HDycX6U3d5ej8_5NWlKU4VTQOuN1hiinBcOk5iLXCPOaQkJYobnSdYELDTORCVURTDjPtagQJRWqqqrOtsDp3HfWFVNdldrGNI2ceTNV_k06ZeTPH2ue5Ni9SIpzltE8Ghx8GXj33OnQyqkJpW4aZbXrgkQ55RlHFIqI7v9CJ67zsfEHxWIJBgmO1PGcKr0Lwet6EQZB-TmJ_JhELiaJir3lDgv-e4MInMyBV9Pot__85OD27HrZHc7FIersWPul1H8EegdrGKXP</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Kubik, Slawomir</creator><creator>Bruzzone, Maria Jessica</creator><creator>Shore, David</creator><general>Nature Publishing Group UK</general><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9859-143X</orcidid></search><sort><creationdate>20170201</creationdate><title>TFIID or not TFIID, a continuing transcriptional SAGA</title><author>Kubik, Slawomir ; 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Although these differences are associated with alternative modes of RNA polymerase II (RNAP II) pre‐initiation complex (PIC) assembly, a role for gene‐specific activators in controlling “regulatability” has been difficult to rule out. To address this question, de Jonge
et al
(
2017
) studied a group of genes controlled by a common activator but dependent on either TFIID or SAGA and found that the magnitude of regulation strongly correlates with the mechanism of PIC assembly.
Graphical Abstract
Alternative modes of transcriptional pre‐initiation complex assembly rather than gene‐specific activators differentiate housekeeping gene expression from regulated gene expression.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28069707</pmid><doi>10.15252/embj.201696152</doi><tpages>2</tpages><orcidid>https://orcid.org/0000-0002-9859-143X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The EMBO journal, 2017-02, Vol.36 (3), p.248-249 |
| issn | 0261-4189 1460-2075 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5286358 |
| source | PubMed Central |
| subjects | EMBO09 EMBO44 Eukaryotes Gene expression Humans News & Views Proteins RNA polymerase Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics TATA-Binding Protein Associated Factors - genetics Transcription Factor TFIID - genetics Transcription, Genetic Views |
| title | TFIID or not TFIID, a continuing transcriptional SAGA |
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