Keep Your Friends Close: Cell-Cell Contact and Skeletal Myogenesis

Development of skeletal muscle is a multistage process that includes lineage commitment of multipotent progenitor cells, differentiation and fusion of myoblasts into multinucleated myofibers, and maturation of myofibers into distinct types. Lineage-specific transcriptional regulation lies at the cor...

Full description

Saved in:
Bibliographic Details
Published in:Cold Spring Harbor perspectives in biology 2017-02, Vol.9 (2), p.a029298
Main Authors: Krauss, Robert S, Joseph, Giselle A, Goel, Aviva J
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Cell Fusion
Cell Lineage
Humans
Muscle Development - physiology
Muscle, Skeletal - cytology
PERSPECTIVES
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Development of skeletal muscle is a multistage process that includes lineage commitment of multipotent progenitor cells, differentiation and fusion of myoblasts into multinucleated myofibers, and maturation of myofibers into distinct types. Lineage-specific transcriptional regulation lies at the core of this process, but myogenesis is also regulated by extracellular cues. Some of these cues are initiated by direct cell-cell contact between muscle precursor cells themselves or between muscle precursors and cells of other lineages. Examples of the latter include interaction of migrating neural crest cells with multipotent muscle progenitor cells, muscle interstitial cells with myoblasts, and neurons with myofibers. Among the signaling factors involved are Notch ligands and receptors, cadherins, Ig superfamily members, and Ephrins and Eph receptors. In this article we describe recent progress in this area and highlight open questions raised by the findings.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a029298