Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer

DNAJB6 also known as mammalian relative of DnaJ (MRJ) encodes a highly conserved member of the DnaJ/Hsp40 family of co-chaperone proteins that function with Hsp70 chaperones. DNAJB6 is widely expressed in all tissues, with higher expression levels detected in the brain. DNAJB6 is involved in diverse...

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Bibliographic Details
Published in:Oncotarget 2016-08, Vol.7 (33), p.53984-53996
Main Authors: Meng, Erhong, Shevde, Lalita A, Samant, Rajeev S
Format: Article
Language:English
Subjects:
HSP40 Heat-Shock Proteins - genetics
HSP40 Heat-Shock Proteins - metabolism
Humans
Molecular Chaperones - genetics
Molecular Chaperones - metabolism
Neoplasms - genetics
Neoplasms - metabolism
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
Protein Isoforms - metabolism
Review
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Summary:DNAJB6 also known as mammalian relative of DnaJ (MRJ) encodes a highly conserved member of the DnaJ/Hsp40 family of co-chaperone proteins that function with Hsp70 chaperones. DNAJB6 is widely expressed in all tissues, with higher expression levels detected in the brain. DNAJB6 is involved in diverse cellular functions ranging from murine placental development, reducing the formation and toxicity of mis-folded protein aggregates, to self-renewal of neural stem cells. Involvement of DNAJB6 is implicated in multiple pathologies such as Huntington's disease, Parkinson's diseases, limb-girdle muscular dystrophy, cardiomyocyte hypertrophy and cancer. This review summarizes the important involvement of the spliced isoforms of DNAJB6 in various pathologies with a specific focus on the emerging roles of human DNAJB6 in cancer and the underlying molecular mechanisms.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.9803