The role of exosomes in the pathogenesis of Alzheimer' disease

Exosomes are small vesicles secreted by most cell types including neurons that function in intercellular communication through transfer of their cargo or encapsulate and eliminate unnecessary cellular components and therefore have a broad impact on nerve development, activation and regeneration. In...

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Bibliographic Details
Published in:Translational neurodegeneration 2017-02, Vol.6 (1), p.3-3, Article 3
Main Authors: Xiao, Tingting, Zhang, Weiwei, Jiao, Bin, Pan, Chu-Zheng, Liu, Xixi, Shen, Lu
Format: Article
Language:English
Subjects:
Biosynthesis
Lipids
Neuroblastoma
Neurons
Pathogenesis
Physiology
Propagation
Proteins
Review
Signal transduction
Studies
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Summary:Exosomes are small vesicles secreted by most cell types including neurons that function in intercellular communication through transfer of their cargo or encapsulate and eliminate unnecessary cellular components and therefore have a broad impact on nerve development, activation and regeneration. In addition, exosomes have been observed to be involved in spreading pathological misfolded proteins, thereby leading to the onset and propagation of disease. Alzheimer disease (AD) is the most common form of dementia and characterized by two types of lesions: amyloid plaques and neurofibrillary tangles. Accumulating evidence has demonstrated that exosomes are associated with amyloid precursor (APP) and Tau proteins and play a controversial role in Alzheimer's disease process. In this review, we will discuss the role of exosomes in the metabolism and secretion of APP and Tau proteins and their subsequent impact on AD pathogenesis.
ISSN:2047-9158
2047-9158
DOI:10.1186/s40035-017-0072-x