APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults: A STROBE Article

To investigate the effect of apolipoprotein E (APOE) gene polymorphism on the resting-state brain function, structure, and blood flow in healthy adults younger than 35 years, using multimodality magnetic resonance (MR) imaging.Seventy-six healthy adults (34 men, 23.7 ± 2.8 y; 31 APOE ε4/ε3 carriers,...

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Published in:Medicine (Baltimore) 2015-12, Vol.94 (52), p.e1734-e1734
Main Authors: Su, Yun Yan, Liang, Xue, Schoepf, U. Joseph, Varga-Szemes, Akos, West, Henry C., Qi, Rongfeng, Kong, Xiang, Chen, Hui Juan, Lu, Guang Ming, Zhang, Long Jiang
Format: Article
Language:English
Subjects:
Adult
Apolipoproteins E - genetics
Brain - pathology
Brain - physiology
Brain - physiopathology
Brain Mapping - methods
Cerebrovascular Circulation - physiology
Female
Humans
Magnetic Resonance Imaging - methods
Male
Neuropsychological Tests
Observational Study
Organ Size
Polymorphism, Genetic
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Summary:To investigate the effect of apolipoprotein E (APOE) gene polymorphism on the resting-state brain function, structure, and blood flow in healthy adults younger than 35 years, using multimodality magnetic resonance (MR) imaging.Seventy-six healthy adults (34 men, 23.7 ± 2.8 y; 31 APOE ε4/ε3 carriers, 31 ε3/ε3 carriers, and 14 ε2/ε3 carriers) were included. For resting-state functional MRI data, default mode network (DMN) and amplitude of low-frequency fluctuation maps were extracted and analyzed. Voxel-based morphometry, diffusion tensor imaging from structural imaging, and cerebral blood flow based on arterial spin labeling MR imaging were also analyzed. Correlation analysis was performed between the above mentioned brain parameters and neuropsychological tests.There were no differences in neuropsychological performances, amplitude of low-frequency fluctuation, gray/white matter volumes, fractional anisotropy, mean diffusivity, or whole brain cerebral blood flow among the 3 groups. As for DMN, the ε4/ε3 group showed increased functional connectivities (FCs) in the left medial prefrontal cortex and bilateral posterior cingulate cortices/precuneus compared with the ε3/ε3 group, and increased FCs in the left medial prefrontal cortex and right temporal lobe compared with the ε2/ε3 group (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000001734