Strong Correlation among Three Biodosimetry Techniques Following Exposures to Ionizing Radiation

Three dose calibration curves for biodosimetry such as dicentric chromosome assay, fluorescence hybridization (FISH) assay for translocation, and micronuclei (MNs) in binucleated cell assay were established after exposure to ionizing radiation. Peripheral blood lymphocyte samples obtained from healt...

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Bibliographic Details
Published in:Genome integrity 2016-01, Vol.7, p.11-11
Main Authors: Kang, Chang-Mo, Yun, Hyun Jin, Kim, Hanna, Kim, Cha Soon
Format: Article
Language:English
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Summary:Three dose calibration curves for biodosimetry such as dicentric chromosome assay, fluorescence hybridization (FISH) assay for translocation, and micronuclei (MNs) in binucleated cell assay were established after exposure to ionizing radiation. Peripheral blood lymphocyte samples obtained from healthy donors were irradiated with Co source at a dose rate of 0.5 Gy/min to doses of 0.1-6 Gy. The results from three dose calibration curves for biodosimetry were analyzed to understand the relationship among biodosimetry assay techniques. Our comparison demonstrates that there is a very strong positive correlation among the dicentric assay, FISH, and MNs analysis, and these three biodosimetry assays strongly support the dose reconstruction and the emergency preparedness of public or occupational radiation overexposure.
ISSN:2041-9414
2041-9414
DOI:10.4103/2041-9414.197168