Transplantation of autologous chondrocytes ex-vivo expanded using Thermoreversible Gelation Polymer in a rabbit model of articular cartilage defect

Abstract Graft failure due to de-differentiation of the chondrocytes during in vitro culture and after transplantation is a major hurdle in Autologous Chondrocyte Implantation (ACI). We, herein, report the transplantation of autologous chondrocytes ex vivo expanded using a Thermo-reversible Gelation...

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Bibliographic Details
Published in:Journal of orthopaedics 2017-06, Vol.14 (2), p.223-225
Main Authors: Arumugam, Sivaraman, Bhupesh Karthik, Balasubramanyan, Chinnuswami, Rajeswar, Mori, Yuichi, Yoshioka, Hiroshi, Senthilkumar, Rajappa, Mathaiyan, Rajmohan, Ramalingam, Karthick, Senthilkumar, Preethy, Abraham, Samuel J.K
Format: Article
Language:English
Subjects:
Articular cartilage
Autologous chondrocyte implantation (ACI)
De-differentiation
Orthopedics
Short Report
Thermo-reversible gelation polymer (TGP)
Tissue engineering
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Summary:Abstract Graft failure due to de-differentiation of the chondrocytes during in vitro culture and after transplantation is a major hurdle in Autologous Chondrocyte Implantation (ACI). We, herein, report the transplantation of autologous chondrocytes ex vivo expanded using a Thermo-reversible Gelation Polymer (TGP) in a rabbit model. A full thickness chondral defect was created in one of the knee joints in each of the six rabbits of the study and autologous chondrocytes in vitro expanded using TGP scaffold were transplanted after 10 weeks. H & E staining of the biopsy after 6 months revealed maintenance of articular cartilage phenotype.
ISSN:0972-978X
0972-978X
DOI:10.1016/j.jor.2017.01.003