Shrimp AHPND-causing plasmids encoding the PirAB toxins as mediated by pirAB-Tn903 are prevalent in various Vibrio species

Acute hepatopancreatic necrosis disease (AHPND) is a newly emerging shrimp disease caused by pirAB toxins encoded by a plasmid found in Vibrio parahaemolyticus . The pirAB toxins are the homologs of the Photorhabdus insect-related (Pir) toxins. Here, we report the complete sequences of the AHPND-cau...

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Bibliographic Details
Published in:Scientific reports 2017-02, Vol.7 (1), p.42177-42177, Article 42177
Main Authors: Xiao, Jinzhou, Liu, Liyuan, Ke, Yiyun, Li, Xiefei, Liu, Yunfei, Pan, Yingjie, Yan, Shuling, Wang, Yongjie
Format: Article
Language:English
Subjects:
45
45/44
631/114/2164
631/326/41
Humanities and Social Sciences
multidisciplinary
Plasmids
Science
Siblings
Transposons
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Summary:Acute hepatopancreatic necrosis disease (AHPND) is a newly emerging shrimp disease caused by pirAB toxins encoded by a plasmid found in Vibrio parahaemolyticus . The pirAB toxins are the homologs of the Photorhabdus insect-related (Pir) toxins. Here, we report the complete sequences of the AHPND-causing plasmid isolated from V. owensii , as well as those of its 11 siblings (pVH family). In addition, we also included 13 related plasmids (pVH-r family) without the pirAB genes isolated from a variety of species within the Vibrio Harveyi clade. Furthermore, the pirAB -Tn903 composite transposon was identified in pVH, and both ends of the transposon appeared to have inserted simultaneously into the ancestor plasmid at different sites. The homologue counterparts of pirAB were also detected in a non-pVH plasmid in V. campbellii . Taken together, our results provide novel insights into the acquisition and evolution of pirAB as well as related plasmids in the Vibrio Harveyi clade.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep42177