Randomized trial evaluating self-sampling for HPV DNA based tests for cervical cancer screening in Nigeria

Cervical cancer incidence and mortality rates in Sub-Saharan Africa (SSA) remain high due to several factors including low levels of uptake of cervical cancer screening. Self-collection of cervicovaginal samples for HPV DNA testing may be an effective modality that can increase uptake of cervical ca...

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Bibliographic Details
Published in:Infectious agents and cancer 2017-02, Vol.12 (1), p.11, Article 11
Main Authors: Modibbo, Fatima, Iregbu, K C, Okuma, James, Leeman, Annemiek, Kasius, Annemieke, de Koning, Maurits, Quint, Wim, Adebamowo, Clement
Format: Article
Language:English
Subjects:
Cancer
Care and treatment
Cervical cancer
Comparative analysis
Diagnosis
DNA
Health aspects
Papillomavirus infections
Prognosis
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Summary:Cervical cancer incidence and mortality rates in Sub-Saharan Africa (SSA) remain high due to several factors including low levels of uptake of cervical cancer screening. Self-collection of cervicovaginal samples for HPV DNA testing may be an effective modality that can increase uptake of cervical cancer screening in SSA and hard to reach populations in developed countries. We investigated whether self-collection of cervicovaginal samples for HPV DNA tests would be associated with increased uptake of screening compared with clinic based collection of samples. Furthermore, we compared the quality of samples collected by both approaches for use in HPV genotyping. We conducted a community based randomized trial in a semi-urban district of Abuja, Nigeria with 400 women, aged 30 to 65 years randomized to either hospital-collection or self-collection of cervicovaginal samples. We compared cervical cancer screening uptake among the 2 groups and evaluated the concentration of human DNA in the samples by measuring RNase P gene levels using qPCR. High-risk HPV DNA detection and typing was done using the GP5+/6+ Luminex system. Most participants in the self-collection arm (93%, 185/200) submitted their samples while only 56% (113/200) of those invited to the hospital for sample collection attended and were screened during the study period ( value 
ISSN:1750-9378
1750-9378
DOI:10.1186/s13027-017-0123-z