Tolerogenic dendritic cells

Deficits in immunological tolerance against self-antigens and antigens provided by the diet and commensal microbiota can result in the development of inflammatory and autoimmune disorders. Dendritic cells (DCs) are pivotal regulators of the immune response, specialized in antigen presentation to dri...

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Bibliographic Details
Published in:Seminars in immunopathology 2017-02, Vol.39 (2), p.113-120
Main Authors: Takenaka, Maisa C., Quintana, Francisco J.
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation - immunology
Autoimmunity
Biomarkers
Biomedical and Life Sciences
Biomedicine
Cell Differentiation
Cell Lineage
Cytokines - metabolism
Dendritic Cells - cytology
Dendritic Cells - immunology
Dendritic Cells - metabolism
Gene Expression
Histocompatibility Antigens Class II - metabolism
Humans
Immune Tolerance
Immunology
Internal Medicine
Perforin - genetics
Receptors, Cholinergic - metabolism
Review
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
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Summary:Deficits in immunological tolerance against self-antigens and antigens provided by the diet and commensal microbiota can result in the development of inflammatory and autoimmune disorders. Dendritic cells (DCs) are pivotal regulators of the immune response, specialized in antigen presentation to drive T cell priming and differentiation. DCs also have a tolerogenic function, participating in the enforcement of central and peripheral tolerance and the resolution of ongoing immune responses. Thus, DCs control effector and regulatory mechanisms relevant to the pathology of autoimmune disorders. In this review, we discuss recent findings regarding the control of the adaptive immune response by tolerogenic DCs. A thorough understanding of the mechanisms that control the tolerogenic DC phenotype will guide the development of novel strategies for the treatment of autoimmunity.
ISSN:1863-2297
1863-2300
DOI:10.1007/s00281-016-0587-8