Integrated Analysis of LncRNA-mRNA Co-Expression Profiles in Patients with Moyamoya Disease

Moyamoya disease (MMD) is an idiopathic disease associated with recurrent stroke. However, the pathogenesis of MMD remains unknown. Therefore, we performed long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression profiles in blood samples from MMD patients (N = 15) and healthy controls (N = 1...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2017-02, Vol.7 (1), p.42421-42421, Article 42421
Main Authors: Wang, Wen, Gao, Faliang, Zhao, Zheng, Wang, Haoyuan, Zhang, Lu, Zhang, Dong, Zhang, Yan, Lan, Qing, Wang, Jiangfei, Zhao, Jizong
Format: Article
Language:English
Subjects:
38
38/61
692/308/2056
692/4017
Cytokines
Digestion
DNA microarrays
DNA probes
Drug metabolism
Gene expression
Humanities and Social Sciences
Inflammation
Kinases
MAP kinase
Metabolism
Moyamoya disease
multidisciplinary
Pathogenesis
Protein kinase
Science
Signal transduction
Stroke
Toll-like receptors
Vitamin A
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Moyamoya disease (MMD) is an idiopathic disease associated with recurrent stroke. However, the pathogenesis of MMD remains unknown. Therefore, we performed long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression profiles in blood samples from MMD patients (N = 15) and healthy controls (N = 10). A total of 880 differentially expressed lncRNAs (3649 probes) and 2624 differentially expressed mRNAs (2880 probes) were obtained from the microarrays of MMD patients and healthy controls (P 2.0). Gene ontology (GO) and pathway analyses showed that upregulated mRNAs were enriched for inflammatory response, Toll-like receptor signaling pathway, chemokine signaling pathway and mitogen-activated protein kinase (MAPK) signaling pathway among others, while the downregulated mRNAs were enriched for neurological system process, digestion, drug metabolism, retinol metabolism and others. Our results showed that the integrated analysis of lncRNA-mRNA co-expression networks were linked to inflammatory response, Toll-like signaling pathway, cytokine-cytokine receptor interaction and MAPK signaling pathway. These findings may elucidate the pathogenesis of MMD, and the differentially expressed genes could provide clues to find key components in the MMD pathway.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep42421