Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP

Cyclic di-guanosine monophosphate (di-GMP) is a circular RNA dinucleotide that functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes, including cell differentiation, conversion between motile and biofilm lifestyles, and virulence gene expression...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2008-07, Vol.321 (5887), p.411-413
Main Authors: SUDARSAN, N, LEE, E. R, WEINBERG, Z, MOY, R. H, KIM, J. N, LINK, K. H, BREAKER, R. R
Format: Article
Language:English
Subjects:
Aptamers, Nucleotide - metabolism
Bacillus cereus - genetics
Bacillus cereus - metabolism
Bacteria
Bacteria - genetics
Bacteria - metabolism
Bacteriology
Bacteriophages - genetics
Base Sequence
Biological and medical sciences
Cellular biology
Clostridioides difficile - genetics
Clostridioides difficile - metabolism
Cyclic GMP - analogs & derivatives
Cyclic GMP - metabolism
Eubacteria
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation, Bacterial
Genes, Bacterial
Genetics
Genomics
Ligands
Microbiology
Molecular Sequence Data
Nucleic Acid Conformation
Regulon
Ribonucleic acid
RNA
RNA, Bacterial - chemistry
RNA, Bacterial - metabolism
RNA, Messenger - chemistry
RNA, Messenger - metabolism
Second Messenger Systems
Vibrio cholerae - genetics
Vibrio cholerae - metabolism
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Summary:Cyclic di-guanosine monophosphate (di-GMP) is a circular RNA dinucleotide that functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes, including cell differentiation, conversion between motile and biofilm lifestyles, and virulence gene expression. However, the mechanisms by which cyclic di-GMP regulates gene expression have remained a mystery. We found that cyclic di-GMP in many bacterial species is sensed by a riboswitch class in messenger RNA that controls the expression of genes involved in numerous fundamental cellular processes. A variety of cyclic di-GMP regulons are revealed, including some riboswitches associated with virulence gene expression, pilus formation, and flagellum biosynthesis. In addition, sequences matching the consensus for cyclic di-GMP riboswitches are present in the genome of a bacteriophage.
ISSN:0036-8075
1095-9203
1095-9203
DOI:10.1126/science.1159519