Pharmacological Basis for Use of Selaginella moellendorffii in Gouty Arthritis: Antihyperuricemic, Anti-Inflammatory, and Xanthine Oxidase Inhibition

This study was aimed at evaluating the effects of Selaginella moellendorffii Hieron. (SM) on gouty arthritis and getting an insight of the possible mechanisms. HPLC method was developed for chemical analysis. The paw oedema, the neutrophil accumulation, inflammatory mediators, lipid peroxidation, an...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2017-01, Vol.2017 (2017), p.1-10
Main Authors: Deng, Guang-rui, Zhang, Guo-li, Chen, Keli, Zhao, Ping, Li, Juan
Format: Article
Language:English
Subjects:
Antioxidants
Arthritis
Care and treatment
Chemical properties
Chinese medicine
Colleges & universities
Crystals
Cytokines
Development and progression
Drug dosages
Enzymes
Experiments
Glycosides
Gout
Health aspects
Immunity
Inflammation
Laboratory animals
Lipid peroxidation
Medicinal plants
Metabolites
Neutrophils
Pharmacokinetics
Pharmacology, Experimental
Pharmacy
Phenols
Physiological aspects
Rheumatism
Rodents
Science
Selaginella
Uric acid
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Summary:This study was aimed at evaluating the effects of Selaginella moellendorffii Hieron. (SM) on gouty arthritis and getting an insight of the possible mechanisms. HPLC method was developed for chemical analysis. The paw oedema, the neutrophil accumulation, inflammatory mediators, lipid peroxidation, and histopathological changes of the joints were analyzed in gouty arthritis rat model, and the kidney injury and serum urate were detected in hyperuricemic mice. Pharmacokinetic result demonstrated that the main apigenin glycosides might be quantitatively transformed into apigenin in the mammalian body. Among these compounds, the apigenin exhibited the strongest effect on xanthine oxidase (XOD). SM aqueous extract has proved to be active in reducing hyperuricemia in dose-dependent manner, and the levels of blood urea nitrogen (BUN) and creatinine (Cr) in high dose group were decreased significantly as compared with hyperuricemic control group (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2017/2103254