Hepatectomy for liver metastases from gastric cancer: a systematic review

Official guidelines recommend palliative treatments for patients with liver metastases from gastric cancer. However, many case series reported that hepatectomy for such cases is safe and effective. This systematic review compares the overall survival between hepatectomy and palliative therapy in pat...

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Bibliographic Details
Published in:BMC surgery 2017-02, Vol.17 (1), p.14-14, Article 14
Main Authors: Liao, Ying-Yang, Peng, Ning-Fu, Long, Di, Yu, Peng-Cheng, Zhang, Sen, Zhong, Jian-Hong, Li, Le-Qun
Format: Article
Language:English
Subjects:
Hepatectomy - methods
Humans
Liver Neoplasms - secondary
Liver Neoplasms - surgery
Stomach Neoplasms - pathology
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Summary:Official guidelines recommend palliative treatments for patients with liver metastases from gastric cancer. However, many case series reported that hepatectomy for such cases is safe and effective. This systematic review compares the overall survival between hepatectomy and palliative therapy in patients with liver metastases from gastric cancer. Two independent reviewers performed a systematic search of literature in EMBASE and PubMed, updated until 26 October 2016. The Newcastle-Ottawa score for cohort studies was used for quality assessment of included studies. A total of eight cohort studies involving 196 patients in the hepatectomy arm and 481 in the palliative arm were included. Median overall survival of patients in the two arms was 23.7 (range, 13.0 to 48.0) and 7.6 (range, 5.5 to 15.2), respectively. Median rates of overall survival of the two arms were 69, 40, 33 and 27, 8, 4% at 1, 2, and 3 years, respectively. Comparing with palliative therapy, hepatectomy was associated with significantly lower mortality at 1 year (odds ratio 0.17, P 
ISSN:1471-2482
1471-2482
DOI:10.1186/s12893-017-0215-0