Clinical impact of surveillance for head and neck cancer in patients with esophageal squamous cell carcinoma

• Published in: World journal of gastroenterology : WJG 2017-02, Vol.23 (6), p.1051-1058
• Main Authors: Morimoto, Hiroyuki, Yano, Tomonori, Yoda, Yusuke, Oono, Yasuhiro, Ikematsu, Hiroaki, Hayashi, Ryuichi, Ohtsu, Atsushi, Kaneko, Kazuhiro
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - diagnostic imaging; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; Chemoradiotherapy; Early Detection of Cancer - methods; Endoscopic Mucosal Resection; Esophageal Neoplasms - diagnostic imaging; Esophageal Neoplasms - mortality; Esophageal Neoplasms - pathology; Esophageal Neoplasms - therapy; Esophageal Squamous Cell Carcinoma; Female; Follow-Up Studies; Head and Neck Neoplasms - diagnostic imaging; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - therapy; Humans; Male; Middle Aged; Narrow Band Imaging; Neoplasm Staging; Neoplasms, Multiple Primary - diagnostic imaging; Neoplasms, Multiple Primary - mortality; Neoplasms, Multiple Primary - pathology; Neoplasms, Multiple Primary - therapy; Neoplasms, Second Primary - diagnostic imaging; Neoplasms, Second Primary - mortality; Neoplasms, Second Primary - pathology; Neoplasms, Second Primary - therapy; Retrospective Studies; Retrospective Study; Squamous Cell Carcinoma of Head and Neck
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v23.i6.1051

AIM To evaluate the clinical impact of surveillance for head and neck(HN) region with narrow band imaging(NBI) in patients with esophageal squamous cell carcinoma(ESCC).METHODS Since 2006, we introduced the surveillance for HN region using NBI for all patients with ESCC beforetreatment, and each follow-up. The patients with newly diagnosed stage Ⅰ to Ⅲ ESCC were enrolled and classified into two groups as follows: Group A(no surveillance for HN region); between 1992 and 2000), and Group B (surveillance for HN region with NBI; between 2006 and 2008). We comparatively evaluated the detection rate of superficial head and neck squamous cell carcinoma (HNSCC), and the serious events due to metachronous advanced HNSCC during the follow-up.RESULTS A total 561 patients(group A: 254, group B: 307) were enrolled. Synchronous superficial HNSCC was detected in 1 patient (0.3%) in group A, and in 12 (3.9%) in group B (P=0.008). During the follow up period, metachronous HNSCC were detected in 10 patients(3.9%) in group A and in 30 patients(9.8%) in group B(P = 0.008). All metachronous lesions in group B were early stage, and 26 patients underwent local resection, however, 6 of 10 patients (60%) in group A lost their laryngeal function and died with metachronous HNSCC.CONCLUSION Surveillance for the HN region by using NBI endoscopy increase the detection rate of early HNSCC in patients with ESCC, and led to decrease serious events related to advanced metachronous HNSCC.