Loss of zfp36 expression in colorectal cancer correlates to wnt/ β-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of zeb1, sox9 and macc1

The mRNA-destabilizing protein ZFP36 has been previously described as a tumor suppressor whose expression is lost during colorectal cancer development. In order to evaluate its role in this disease, we restored ZFP36 expression in different cell contexts, showing that the presence of this protein im...

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Published in:Oncotarget 2016-09, Vol.7 (37), p.59144-59157
Main Authors: Montorsi, Lucia, Guizzetti, Filippo, Alecci, Claudia, Caporali, Andrea, Martello, Andrea, Atene, Claudio Giacinto, Parenti, Sandra, Pizzini, Silvia, Zanovello, Paola, Bortoluzzi, Stefania, Ferrari, Sergio, Grande, Alexis, Zanocco-Marani, Tommaso
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cited_by cdi_FETCH-LOGICAL-c343t-cb487991a82db10684bde586843e0d5f3d28af13ec7c39704c8b5ca4a479cbde3
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container_end_page 59157
container_issue 37
container_start_page 59144
container_title Oncotarget
container_volume 7
creator Montorsi, Lucia
Guizzetti, Filippo
Alecci, Claudia
Caporali, Andrea
Martello, Andrea
Atene, Claudio Giacinto
Parenti, Sandra
Pizzini, Silvia
Zanovello, Paola
Bortoluzzi, Stefania
Ferrari, Sergio
Grande, Alexis
Zanocco-Marani, Tommaso
description The mRNA-destabilizing protein ZFP36 has been previously described as a tumor suppressor whose expression is lost during colorectal cancer development. In order to evaluate its role in this disease, we restored ZFP36 expression in different cell contexts, showing that the presence of this protein impairs the epithelial-to-mesenchymal transition (EMT) and induces a higher susceptibility to anoikis. Consistently, we found that ZFP36 inhibits the expression of three key transcription factors involved in EMT: ZEB1, MACC1 and SOX9. Finally, we observed for the first time that its expression negatively correlates with the activity of Wnt/β-catenin pathway, which is constitutively activated in colorectal cancer. This evidence provides a clue on the mechanism leading to the loss of ZFP36 in CRC.
doi_str_mv 10.18632/oncotarget.10828
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title Loss of zfp36 expression in colorectal cancer correlates to wnt/ β-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of zeb1, sox9 and macc1
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