Antioxidant Properties and Cardioprotective Mechanism of Malaysian Propolis in Rats

Propolis contains high concentrations of polyphenols, flavonoids, tannins, ascorbic acid, and reducing sugars and proteins. Malaysian Propolis (MP) has been reported to exhibit high 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity and ferric reducing antioxidant power (FRAP) values....

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2017-01, Vol.2017 (2017), p.1-11
Main Authors: Khalil, Md. Ibrahim, Sulaiman, Siti Amrah, Paul, Sudip, Rumpa, Nur-E-Noushin, Ahmmed, Istiyak, Afroz, Rizwana, Hossen, Md. Sakib, Tanvir, E. M., Ahmed, Romana, Gan, Siew Hua
Format: Article
Language:English
Subjects:
Antioxidants
Dietary minerals
Enzymes
Flavonoids
Free radicals
Gangrene
Genetic aspects
Heart
Heart attack
Isoflavones
Polyphenols
Propolis
R&D
Rats
Rattus
Research & development
Rodents
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Summary:Propolis contains high concentrations of polyphenols, flavonoids, tannins, ascorbic acid, and reducing sugars and proteins. Malaysian Propolis (MP) has been reported to exhibit high 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity and ferric reducing antioxidant power (FRAP) values. Herein, we report the antioxidant properties and cardioprotective properties of MP in isoproterenol- (ISO-) induced myocardial infarction in rats. Male Wistar rats (n=32) were pretreated orally with an ethanol extract of MP (100 mg/kg/day) for 30 consecutive days. Subcutaneous injection of ISO (85 mg/kg in saline) for two consecutive days caused a significant increase in serum cardiac marker enzymes and cardiac troponin I levels and altered serum lipid profiles. In addition significantly increased lipid peroxides and decreased activities of cellular antioxidant defense enzymes were observed in the myocardium. However, pretreatment of ischemic rats with MP ameliorated the biochemical parameters, indicating the protective effect of MP against ISO-induced ischemia in rats. Histopathological findings obtained for the myocardium further confirmed the biochemical findings. It is concluded that MP exhibits cardioprotective activity against ISO-induced oxidative stress through its direct cytotoxic radical-scavenging activities. It is also plausible that MP contributed to endogenous antioxidant enzyme activity via inhibition of lipid peroxidation.
ISSN:1741-427X
1741-4288
DOI:10.1155/2017/5370545