Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites

Ambient particulate matter (PM) exposure is associated with atherosclerosis and inflammatory bowel disease. Ultrafine particles (UFP, d p  

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Bibliographic Details
Published in:Scientific reports 2017-02, Vol.7 (1), p.42906, Article 42906
Main Authors: Li, Rongsong, Yang, Jieping, Saffari, Arian, Jacobs, Jonathan, Baek, Kyung In, Hough, Greg, Larauche, Muriel H., Ma, Jianguo, Jen, Nelson, Moussaoui, Nabila, Zhou, Bill, Kang, Hanul, Reddy, Srinivasa, Henning, Susanne M., Campen, Matthew J., Pisegna, Joseph, Li, Zhaoping, Fogelman, Alan M., Sioutas, Constantinos, Navab, Mohamad, Hsiai, Tzung K.
Format: Article
Language:English
Subjects:
13
13/21
13/51
45/22
45/23
631/92/287/1194
64/110
692/4019/592/75/593/2100
82/16
82/58
Abundance
Airborne particulates
Animals
Arteriosclerosis
Atherosclerosis
Bacteria - genetics
Bacteria - isolation & purification
Cecum
Cecum - metabolism
Cholestanol - metabolism
Cholesterol
Cholesterol - metabolism
Cyanobacteria
Cytokines - blood
Diet, High-Fat
Digestive system
Gastrointestinal Microbiome - drug effects
Gastrointestinal tract
High fat diet
Humanities and Social Sciences
Inflammatory bowel diseases
Ingestion
Intestinal microflora
Intestine
Lipid Metabolism - drug effects
Lipids
Low density lipoprotein receptors
Lysophosphatidylcholine
Lysophosphatidylcholines - analysis
Lysophosphatidylcholines - blood
Lysophospholipids - analysis
Lysophospholipids - blood
Macrophages
Macrophages - cytology
Macrophages - immunology
Metabolites
Mice
Mice, Knockout
multidisciplinary
Oral administration
Particulate matter
Particulate Matter - chemistry
Particulate Matter - pharmacology
Plasma
Principal Component Analysis
Principal components analysis
Receptor density
Receptors, LDL - deficiency
Receptors, LDL - genetics
RNA, Ribosomal, 16S - genetics
RNA, Ribosomal, 16S - metabolism
Science
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Description
Summary:Ambient particulate matter (PM) exposure is associated with atherosclerosis and inflammatory bowel disease. Ultrafine particles (UFP, d p  
ISSN:2045-2322
2045-2322
DOI:10.1038/srep42906