Effect of Medications for Gastric Acid-Related Symptoms on Total Motile Sperm Count and Concentration: A Case–Control Study in Men of Subfertile Couples from the Netherlands

Introduction Gastric acid-related symptoms are highly prevalent in the general population (21–40%), and more than 11% of individuals use medication for the treatment of these symptoms. The uptake of micronutrients is dependent on the gastrointestinal potential of hydrogen (pH). Objective We hypothes...

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Bibliographic Details
Published in:Drug safety 2017-03, Vol.40 (3), p.241-248
Main Authors: Huijgen, Nicole A., Goijen, Hedwig J., Twigt, John M., Mulders, Annemarie G. M. G. J., Lindemans, Jan, Dohle, Gert R., Laven, Joop S. E., Steegers-Theunissen, Régine P. M.
Format: Article
Language:English
Subjects:
Acids
Alcohol use
Blood cells
Body mass index
Carbon
Counseling
Couples
Drug Safety and Pharmacovigilance
Drugs
Erythrocytes
Fertility
Folic acid
Homocysteine
Laboratories
Medicine
Medicine & Public Health
Men
Mens health
Metabolism
Micronutrients
Motility
Original
Original Research Article
pH effects
Pharmacology/Toxicology
Pregnancy
Quality
Semen
Smoking
Sperm
Spermatogenesis
Studies
Vitamin B
Vitamins
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Summary:Introduction Gastric acid-related symptoms are highly prevalent in the general population (21–40%), and more than 11% of individuals use medication for the treatment of these symptoms. The uptake of micronutrients is dependent on the gastrointestinal potential of hydrogen (pH). Objective We hypothesized that medication affecting gastrointestinal pH reduces the availability of B vitamins, thereby deranging one-carbon metabolism and detrimentally affecting spermatogenesis. Methods This explorative nested case–control study in men of subfertile couples investigated associations between medication used for gastric acid-related symptoms and semen parameters. We included 40 men using medication for gastric acid-related symptoms and 843 men not using medication. Semen analyses were performed between 70 days before and 21 days after the visit. Results The use of medication was associated with a twofold higher risk of a low total motile sperm count [TMSC
ISSN:0114-5916
1179-1942
DOI:10.1007/s40264-016-0488-8