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The Correlation and Risk Factors between Carotid Intima-Media Thickening and Alcoholic Liver Disease Coupled with Helicobacter pylori Infection
The aim of this study was to explore the associations and differences in influencing factors between alcoholic liver disease (ALD) coupled with Helicobacter pylori infection and atherosclerosis and to determine whether there is a “double hit phenomenon” in atherosclerosis patients with ALD and H. py...
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Published in: | Scientific reports 2017-02, Vol.7 (1), p.43059, Article 43059 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The aim of this study was to explore the associations and differences in influencing factors between alcoholic liver disease (ALD) coupled with
Helicobacter pylori
infection and atherosclerosis and to determine whether there is a “double hit phenomenon” in atherosclerosis patients with ALD and
H. pylori
infections. Included cases (n = 160) were categorized into 4 groups: 41 cases of ALD coupled with
H. pylori
infections (group A), 35 cases of
H. pylori
infections without ALD (group B), 37 cases of ALD without
H. pylori
infections (group C), and 47 normal control cases (group D). CIMT was significantly greater in group A than in groups B and D (P = 0.005 and P = 0.001, respectively). The GLM univariate analysis found that CIMT was significantly greater in group A than in groups B, C and D (P = 0.018, P = 0.001 and P = 0.009, respectively). We found that BMI and ALT, AST and ApoB levels were independent predictors of CIMT (P = 0.000, P = 0.000, P = 0.012 and P = 0.014, respectively). ALD coupled with
H. pylori
infection may result in significant CIMT thickening, but
H. pylori
infection without ALD and ALD without
H. pylori
infection does not, suggesting that a “double hit phenomenon” occurs. Additionally, BMI, and ALT, AST and ApoB levels were independent risk factors for increased CIMT. |
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ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/srep43059 |