Dendritic cells derived exosomes migration to spleen and induction of inflammation are regulated by CCR7

Mature dendritic cells (DCs) home to secondary lymphoid organs through CC chemokine receptor 7 (CCR7). Exosomes derived from DCs (DC-exos) are reported to migrate to spleen and induce inflammation in vivo . In this study, we demonstrated that mature bone marrow DC-exos can activate immature DC and T...

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Bibliographic Details
Published in:Scientific reports 2017-02, Vol.7 (1), p.42996-42996, Article 42996
Main Authors: Wei, Gao, Jie, Yuan, Haibo, Liu, Chaoneng, Wu, Dong, Huang, Jianbing, Zhu, Junjie, Guo, Leilei, Ma, Hongtao, Shi, Yunzeng, Zou, Junbo, Ge
Format: Article
Language:English
Subjects:
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13/89
14/19
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631/250/98
Bone marrow
CC chemokine receptors
CCR7 protein
Dendritic cells
Exosomes
Humanities and Social Sciences
Inflammation
Leukocyte migration
Lymphocytes T
multidisciplinary
Rodents
Science
Spleen
T cell receptors
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Summary:Mature dendritic cells (DCs) home to secondary lymphoid organs through CC chemokine receptor 7 (CCR7). Exosomes derived from DCs (DC-exos) are reported to migrate to spleen and induce inflammation in vivo . In this study, we demonstrated that mature bone marrow DC-exos can activate immature DC and T cells in vitro . Then we intravenously injected DC-exos into C57BL/6 mice, observing that mature DC-exos accumulated more in spleen than immature DC-exos. These DC-exos in spleen could be uptaken by splenetic DCs and T cells and induce an inflammatory response. We further showed that the increased accumulation of mature DC-exos in spleen was regulated by CCR7, whose reduction led to a decrease of accumulation in spleen and attenuated inflammatory response in serum. These data provide us a new perspective to comprehensively understand exosomes, which might inherit some special functions from their parent cells and exert these functions in vivo .
ISSN:2045-2322
2045-2322
DOI:10.1038/srep42996