Cytotrophoblast, Not Syncytiotrophoblast, Dominates Glycolysis and Oxidative Phosphorylation in Human Term Placenta

The syncytiotrophoblast (SCT) at the maternal-fetal interface has been presumed to be the primary driver of placental metabolism, and the underlying progenitor cytotrophoblast cells (CTB) an insignificant contributor to placental metabolic activity. However, we now show that the metabolic rate of CT...

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Bibliographic Details
Published in:Scientific reports 2017-02, Vol.7 (1), p.42941-42941, Article 42941
Main Authors: Kolahi, Kevin S., Valent, Amy M., Thornburg, Kent L.
Format: Article
Language:English
Subjects:
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Acidification
Cell culture
Deoxyribonucleic acid
DNA
Epidermal growth factor
Explants
Fetuses
Gestation
Glycolysis
Humanities and Social Sciences
MAP kinase
Metabolic rate
Metabolism
Mitochondria
multidisciplinary
Oxidative phosphorylation
Oxygen consumption
Phosphorylation
Placenta
Science
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Summary:The syncytiotrophoblast (SCT) at the maternal-fetal interface has been presumed to be the primary driver of placental metabolism, and the underlying progenitor cytotrophoblast cells (CTB) an insignificant contributor to placental metabolic activity. However, we now show that the metabolic rate of CTB is much greater than the SCT. The oxygen consumption and extracellular acidification rate, a measure of glycolysis, are both greater in CTB than in SCT in vitro (CTB: 96 ± 16 vs SCT: 46 ± 14 pmol O 2  × min −1  × 100 ng DNA −1 , p 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep42941