Dual Infection with Hepatitis B and Epstein-Barr Virus Presenting with Severe Jaundice, Coagulopathy, and Hepatitis B Virus Chronicity Outcome

BACKGROUND Hepatitis B virus (HBV) has been reported as a coinfection with hepatitis C virus (HCV), hepatitis D virus (HDV), cytomegalovirus (CMV), and human immunodeficiency virus (HIV). CASE REPORT A 34-year-old female presented to our clinic with epigastric pain and severe acute hepatitis manifes...

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Bibliographic Details
Published in:The American journal of case reports 2017-02, Vol.18, p.170-172
Main Authors: Rao, Sirish C, Ashraf, Imran, Mir, Fazia, Samiullah, Sami, Ibdah, Jamal A, Tahan, Veysel
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Blood Coagulation Disorders - virology
Coinfection
Diagnosis, Differential
Female
Hepatitis B - blood
Hepatitis B - complications
Hepatitis B - diagnosis
Hepatitis B virus - isolation & purification
Hepatitis B, Chronic - complications
Hepatitis B, Chronic - diagnosis
Herpesvirus 4, Human - isolation & purification
Humans
Hyperbilirubinemia - blood
Infectious Mononucleosis - blood
Infectious Mononucleosis - complications
Infectious Mononucleosis - diagnosis
Jaundice - virology
Severity of Illness Index
Transaminases - blood
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Summary:BACKGROUND Hepatitis B virus (HBV) has been reported as a coinfection with hepatitis C virus (HCV), hepatitis D virus (HDV), cytomegalovirus (CMV), and human immunodeficiency virus (HIV). CASE REPORT A 34-year-old female presented to our clinic with epigastric pain and severe acute hepatitis manifested as jaundice associated with hyperbilirubinemia, elevated transaminases, and coagulopathy. The patient was diagnosed with acute HBV with Epstein-Barr virus (EBV) coinfection leading to subsequent chronic hepatitis B. CONCLUSIONS To our knowledge, this patient case is the first reported case of HBV and EBV coinfection reported in the literature. HBV and EBV coinfection may cause severe acute hepatitis with HBV chronicity.
ISSN:1941-5923
1941-5923
DOI:10.12659/AJCR.901688