Anti-Müllerian Hormone in Obese Adolescent Girls With Polycystic Ovary Syndrome

Abstract Purpose Anti-Müllerian hormone (AMH) is proposed as a biomarker of polycystic ovary syndrome (PCOS). This study investigated: (1) AMH concentrations in obese adolescents with PCOS versus without PCOS; (2) the relationship of AMH to sex steroid hormones, adiposity, and insulin resistance; an...

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Bibliographic Details
Published in:Journal of adolescent health 2017-03, Vol.60 (3), p.333-339
Main Authors: Kim, Joon Young, Ph.D, Tfayli, Hala, M.D, Michaliszyn, Sara F., Ph.D, Lee, SoJung, Ph.D, Nasr, Alexis, M.D, Arslanian, Silva, M.D
Format: Article
Language:English
Subjects:
Adolescent
Adolescent girls
AMH
Anti-Mullerian Hormone - blood
Biological markers
Biomarkers - blood
Body composition
Cross-Sectional Studies
Female
Girls
Hormones
Humans
Hyperandrogenemia
Insulin
Medical diagnosis
Obese adolescents
Obesity
PCOS
Pediatric Obesity - blood
Pediatric Obesity - complications
Pediatrics
Polycystic ovarian syndrome
Polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
Power
Prediction models
Puberty
Reproductive health
Resistance
Teenagers
Testosterone
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Summary:Abstract Purpose Anti-Müllerian hormone (AMH) is proposed as a biomarker of polycystic ovary syndrome (PCOS). This study investigated: (1) AMH concentrations in obese adolescents with PCOS versus without PCOS; (2) the relationship of AMH to sex steroid hormones, adiposity, and insulin resistance; and (3) the optimal AMH value and the multivariable prediction model to determine PCOS in obese adolescents. Methods AMH levels were measured in 46 obese PCOS girls and 43 obese non-PCOS girls. Sex steroid hormones, clamp-measured insulin sensitivity and secretion, body composition, and abdominal adiposity were evaluated. Logistic regression and receiver-operating characteristic curve analyses were used, and multivariate prediction models were developed to test the utility of AMH for the diagnosis of PCOS. Results AMH levels were higher in obese PCOS versus non-PCOS girls (8.3 ± .6 vs. 4.3 ± .4 ng/mL, p  
ISSN:1054-139X
1879-1972
DOI:10.1016/j.jadohealth.2016.10.015