Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action

Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies sh...

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Bibliographic Details
Published in:Theranostics 2017-01, Vol.7 (2), p.425-435
Main Authors: Ai, Xiao-Yu, Liu, Hui-Juan, Lu, Cheng, Liang, Cai-Li, Sun, Yan, Chen, Shuang, Sun, Bo, Li, Yang, Liu, Yan-Rong, Zhang, Qiang, Liu, Xue-Qiang, Xiao, Ting, Jing, Xue-Shuang, Sun, Tao, Zhou, Hong-Gang, Yang, Cheng
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents, Local - administration & dosage
Cytokine Receptor gp130 - agonists
Disease Models, Animal
Immunologic Factors - administration & dosage
Janus Kinases - metabolism
Nanostructures - administration & dosage
Phenytoin - administration & dosage
Rats, Sprague-Dawley
Research Paper
Signal Transduction
Silver - administration & dosage
STAT3 Transcription Factor - metabolism
Swine
Swine, Miniature
Treatment Outcome
Wound Healing - drug effects
Wounds and Injuries - drug therapy
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Summary:Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could accelerate dermal wound healing and strong inflammation control in Sprague-Dawley rats (SD rat) and Bama minipigs. Due to its low solubility, PnAg led to low toxicity and blood enrichment in animals. Furthermore, PnAg could upregulate the promoter activity of Jak, Stat3, and Stat3 downstream proteins. Therefore, PnAg may serve as an effective therapeutic compound for wound healing through regulating the gp130/Jak/Stat3 signaling pathway.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.17073