Association between CHADS2 score, depressive symptoms, and quality of life in a general population

• Published in: BMC psychiatry 2017-02, Vol.17 (1), p.80-80, Article 80
• Main Authors: Sun, Guo-Zhe, Ye, Ning, Zhang, Nai-Jin, Li, Yuan, Chen, Shuang, Chang, Ye, Li, Zhao, Sun, Ying-Xian
• Format: Article
• Language: English
• Subjects: Blood pressure; Cholesterol; Data collection; Diabetes; Epidemiology; Heart failure; Hypertension; Ischemia; Mental depression; Mortality; Population; Psychiatry; Quality of life; Quality standards; Questionnaires; Stroke; Transient ischemic attack
• ISSN: 1471-244X; 1471-244X
• DOI: 10.1186/s12888-017-1214-5

Background To investigate the association between CHADS2 score, depressive symptoms, and quality of life in a large general population from China. Methods A cross-sectional study of 11,956 permanent residents of Liaoning Province in China ≥ 35 years of age was conducted between January and August 2013 (response rate 85.3%). All participants completed a questionnaire, had a physical examination, and underwent blood examination. Depressive symptoms were assessed with the Patient Health Questionnaire-9 (PHQ-9), while the quality of life (QoL) was measured using the World Health Organization Quality of Life Brief Scale (WHOQOL-BREF). Results With increasing CHADS2 score, the prevalence of depressive symptoms increased from 4.9 to 27.8% (P < 0.001), and all scores of WHOQOL-BREF decreased significantly (all Ps < 0.001). After adjusting for confounding risk factors, subjects with CHADS2 score ≥ 3 had higher risk of depressive symptoms than those with CHADS2 score = 0 (all Ps < 0.05). Also, CHADS2 score was negatively associated with all scores of WHOQOL-BREF (all Ps < 0.001). Furthermore, subjects with any item in CHADS2 had higher prevalence of depressive symptoms (all Ps < 0.001). Heart failure and stroke remained independently associated with depressive symptoms after adjusting for confounding risk factors and other items (Ps < 0.001), while heart failure, age ≥ 75 years, diabetes mellitus, and stroke were all independently negatively associated with the total score of WHOQOL-BREF (all Ps < 0.05). Conclusions The CHADS2 score is significantly associated with depressive symptoms and impaired quality of life in the general population.