High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model

is emerging with resistance to polymyxins. In 24-h time-kill experiments, high-dose ampicillin-sulbactam in combination with meropenem and polymyxin B achieved additivity or synergy against 10 CFU/ml of two clinical isolates resistant to all three drugs (maximum reductions, 1.6 and 3.1 logs). In a 1...

Full description

Saved in:
Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2017-03, Vol.61 (3)
Main Authors: Lenhard, Justin R, Smith, Nicholas M, Bulman, Zackery P, Tao, Xun, Thamlikitkul, Visanu, Shin, Beom S, Nation, Roger L, Li, Jian, Bulitta, Jürgen B, Tsuji, Brian T
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Acinetobacter baumannii - drug effects
Acinetobacter baumannii - growth & development
Acinetobacter Infections - drug therapy
Acinetobacter Infections - microbiology
Ampicillin - blood
Ampicillin - pharmacokinetics
Anti-Bacterial Agents
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
Area Under Curve
Biological Availability
Body Mass Index
Drug Administration Schedule
Drug Combinations
Drug Dosage Calculations
Drug Resistance, Multiple, Bacterial
Drug Synergism
Humans
Microbial Sensitivity Tests
Models, Statistical
Pharmacology
Polymyxin B
Polymyxin B - blood
Polymyxin B - pharmacokinetics
Sulbactam - blood
Sulbactam - pharmacokinetics
Thienamycins
Thienamycins - blood
Thienamycins - pharmacokinetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:is emerging with resistance to polymyxins. In 24-h time-kill experiments, high-dose ampicillin-sulbactam in combination with meropenem and polymyxin B achieved additivity or synergy against 10 CFU/ml of two clinical isolates resistant to all three drugs (maximum reductions, 1.6 and 3.1 logs). In a 14-day hollow-fiber infection model, high-dose ampicillin-sulbactam (8/4 g every 8 h, respectively) in combination with meropenem (2 g every 8 h) and polymyxin B (1.43 mg/kg of body weight every 12 h with loading dose) resulted in rapid (96 h) eradication of .
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01268-16