Effect of HIV-1 envelope cytoplasmic tail on adenovirus primed virus encoded virus-like particle immunizations

Highlights • Adenoviral heterologous prime-double boost continuously increase antibody responses. • CON-S CT truncation increases antigen presentation with a bias towards gp120 epitopes. • Priming with an Env CT truncated VLP vaccine skews antibody responses towards gp120.

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Bibliographic Details
Published in:Vaccine 2016-10, Vol.34 (44), p.5344-5351
Main Authors: Andersson, Anne-Marie C, Ragonnaud, Emeline, Seaton, Kelly E, Sawant, Sheetal, Folgori, Antonella, Colloca, Stefano, Labranche, Celia, Montefiori, David C, Tomaras, Georgia D, Holst, Peter J
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adenoviral vectors
Adenoviridae
Adenoviridae - genetics
Adenoviridae - immunology
Adenoviruses, Human - genetics
Adenoviruses, Human - immunology
AIDS
AIDS Vaccines - administration & dosage
AIDS Vaccines - genetics
AIDS Vaccines - immunology
Allergy and Immunology
Animals
Antibodies, Neutralizing - blood
Antibodies, Neutralizing - immunology
Antigens
Binding sites
Conflicts of interest
env Gene Products, Human Immunodeficiency Virus - immunology
Envelope
Epitopes - immunology
Genes, gag
Genetic Vectors
HIV
HIV Antibodies - blood
HIV Antibodies - immunology
HIV Envelope Protein gp120 - immunology
HIV-1 - immunology
Human immunodeficiency virus
Humoral immunity
Immunity, Humoral
Immunization
Immunogenicity, Vaccine
Immunoglobulins
Lentivirus
Mice, Inbred BALB C
Neutralization
Pan troglodytes
Simian Immunodeficiency Virus - genetics
Simian Immunodeficiency Virus - immunology
Vaccine
Vaccines
Vaccines, Virus-Like Particle - immunology
Virus-like particles
Viruses
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Items that cite this one
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Description
Summary:Highlights • Adenoviral heterologous prime-double boost continuously increase antibody responses. • CON-S CT truncation increases antigen presentation with a bias towards gp120 epitopes. • Priming with an Env CT truncated VLP vaccine skews antibody responses towards gp120.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.08.089