Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second

Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arte...

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Bibliographic Details
Published in:Biomedical optics express 2017-02, Vol.8 (2), p.943-953
Main Authors: Wu, Min, Springeling, Geert, Lovrak, Matija, Mastik, Frits, Iskander-Rizk, Sophinese, Wang, Tianshi, van Beusekom, Heleen M M, van der Steen, A F W, Van Soest, Gijs
Format: Article
Language:English
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Summary:Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arteries in vivo, at a clinically useful frame rate of 20 s . We confirmed image contrast for atherosclerotic plaque in human samples ex vivo. The system is on a mobile platform and provides real-time data visualization during acquisition. We achieved an IVPA signal-to-noise ratio of 20 dB. These data show that clinical translation of IVPA is possible in principle.
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.8.000943