Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second

Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arte...

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Published in:Biomedical optics express 2017-02, Vol.8 (2), p.943-953
Main Authors: Wu, Min, Springeling, Geert, Lovrak, Matija, Mastik, Frits, Iskander-Rizk, Sophinese, Wang, Tianshi, van Beusekom, Heleen M M, van der Steen, A F W, Van Soest, Gijs
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cited_by cdi_FETCH-LOGICAL-c427t-5587ef4d301c42e2cf2f34c90a158ecbce2ce878ec6781afeb8e1f74002fba53
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container_issue 2
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container_title Biomedical optics express
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creator Wu, Min
Springeling, Geert
Lovrak, Matija
Mastik, Frits
Iskander-Rizk, Sophinese
Wang, Tianshi
van Beusekom, Heleen M M
van der Steen, A F W
Van Soest, Gijs
description Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arteries in vivo, at a clinically useful frame rate of 20 s . We confirmed image contrast for atherosclerotic plaque in human samples ex vivo. The system is on a mobile platform and provides real-time data visualization during acquisition. We achieved an IVPA signal-to-noise ratio of 20 dB. These data show that clinical translation of IVPA is possible in principle.
doi_str_mv 10.1364/BOE.8.000943
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title Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second
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