Blunted striatal response to monetary reward anticipation during smoking abstinence predicts lapse during a contingency-managed quit attempt

Rationale Tobacco smoking is associated with dysregulated reward processing within the striatum, characterized by hypersensitivity to smoking rewards and hyposensitivity to non-smoking rewards. This bias toward smoking reward at the expense of alternative rewards is further exacerbated by deprivatio...

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Bibliographic Details
Published in:Psychopharmacology 2016-03, Vol.233 (5), p.751-760
Main Authors: Sweitzer, Maggie M., Geier, Charles F., Denlinger, Rachel, Forbes, Erika E., Raiff, Bethany R., Dallery, Jesse, McClernon, F. J., Donny, Eric C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anticipation, Psychological
Biomedical and Life Sciences
Biomedicine
Brain
Craving
Drug addiction
Female
Health aspects
Humans
Individuality
Magnetic Resonance Imaging
Male
Middle Aged
Motivation
Neostriatum - physiopathology
Neurosciences
Nicotine
Original Investigation
Pharmacology/Toxicology
Psychiatry
Psychological aspects
Psychopharmacology
Recurrence
Reward
Rewards (Psychology)
Smoking
Smoking - physiopathology
Smoking - psychology
Smoking cessation
Smoking Cessation - psychology
Substance Withdrawal Syndrome - physiopathology
Substance Withdrawal Syndrome - psychology
Young Adult
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Summary:Rationale Tobacco smoking is associated with dysregulated reward processing within the striatum, characterized by hypersensitivity to smoking rewards and hyposensitivity to non-smoking rewards. This bias toward smoking reward at the expense of alternative rewards is further exacerbated by deprivation from smoking, which may contribute to difficulty maintaining abstinence during a quit attempt. Objective We examined whether abstinence-induced changes in striatal processing of rewards predicted lapse likelihood during a quit attempt supported by contingency management (CM), in which abstinence from smoking was reinforced with money. Methods Thirty-six non-treatment-seeking smokers participated in two functional MRI (fMRI) sessions, one following 24-h abstinence and one following smoking as usual. During each scan, participants completed a rewarded guessing task designed to elicit striatal activation in which they could earn smoking and monetary rewards delivered after the scan. Participants then engaged in a 3-week CM-supported quit attempt. Results As previously reported, 24-h abstinence was associated with increased striatal activation in anticipation of smoking reward and decreased activation in anticipation of monetary reward. Individuals exhibiting greater decrements in right striatal activation to monetary reward during abstinence (controlling for activation during non-abstinence) were more likely to lapse during CM ( p  
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-015-4152-2