Proteomic Analysis of Liver Proteins in a Rat Model of Chronic Restraint Stress-Induced Depression

Depression is a global mental disorder disease and greatly threatened human health and stress is considered to be one of the important factors that lead to depression. In this study, we used newly developed iTRAQ labeling and high performance liquid chromatography (HPLC) and mass spectrum united ana...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-14
Main Authors: Sun, Wei, Ronghua, Zhao, Guo, Zhengguang, Li, Cong, Xie, Ming
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Chromatography
Chromatography, High Pressure Liquid
Databases, Protein
Depression - complications
Depression - metabolism
Disease Models, Animal
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Immobilization
Lipids
Liver - metabolism
Male
Metabolism
Metabolites
Pathogenesis
Physiology
Proteins
Proteomics
Proteomics - methods
Rats
Rats, Wistar
Ribosomal Proteins - chemistry
Rodents
Signal Transduction
Software
Stress, Psychological
Studies
Tandem Mass Spectrometry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Depression is a global mental disorder disease and greatly threatened human health and stress is considered to be one of the important factors that lead to depression. In this study, we used newly developed iTRAQ labeling and high performance liquid chromatography (HPLC) and mass spectrum united analysis technology obtained the 2176 accurate proteins. Successively, we used the GO analysis and IPA software to analyze the 98 differentially expressed proteins of liver in depression rats due to chronic restraint stress, showing a map of proteomics analysis of liver proteins from the aspects of related functions, disease and function analysis, canonical pathway analysis, and associated network. This study provide important information for comprehensively understanding the mechanisms of dysfunction or injury in the liver in depression.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/7508316