Pathogenesis of Proliferative Lupus Nephritis from a Historical and Personal Perspective

Highlights • Multiple immune complexes are involved in lupus nephritis. • DNA/anti-dsDNA and nucleosome/anti-nucleosome are neither the only nor the most important immune complexes in lupus nephritis. • Lupus nephritis may be initiated by autoantibodies of several or multiple specificities. • Deposi...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2017-12, Vol.185, p.51-58
Main Authors: Fu, Shu Man, Wang, Hongyang, Dai, Chao, Sung, Sun-sang J, Gaskin, Felicia
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antigen-Antibody Complex
Autoimmune diseases
Autoimmunity
End organ resistance to damage
Humans
Immune complex-mediated diseases
Lupus nephritis
Lupus Nephritis - immunology
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Summary:Highlights • Multiple immune complexes are involved in lupus nephritis. • DNA/anti-dsDNA and nucleosome/anti-nucleosome are neither the only nor the most important immune complexes in lupus nephritis. • Lupus nephritis may be initiated by autoantibodies of several or multiple specificities. • Deposition of immune complexes with complement activation may not be sufficient to induce progression of acute glomerulonephritis to chronic glomerulonephritis. • Local factors may determine the outcomes of immune-complex mediated lupus proliferative glomerulonephritis.
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2016.07.024