Association between the ratio of triglyceride to high‐density lipoprotein cholesterol and incident type 2 diabetes in Singapore Chinese men and women

• Published in: Journal of diabetes 2017-07, Vol.9 (7), p.689-698
• Main Authors: Wang, Ye‐Li, Koh, Woon‐Puay, Talaei, Mohammad, Yuan, Jian‐Min, Pan, An
• Format: Article
• Language: English
• Subjects: 2型糖尿病; Diabetes; Health risk assessment; high‐density lipoprotein cholesterol; Low density lipoprotein; Mens health; nested case–control study; triglycerides; type 2 diabetes mellitus; Womens health; 三酰甘油; 巢式病例对照研究; 高密度脂蛋白胆固醇
• ISSN: 1753-0393; 1753-0407
• DOI: 10.1111/1753-0407.12477

Background Increased triglycerides (TG) and decreased high‐density lipoprotein cholesterol (HDL‐C) are risk factors for type 2 diabetes (T2D). The relationship between TG:HDL‐C ratio and T2D risk is not clear, and it is not known whether the association is modified by gender, body mass index, or fasting status. This study examined the relationship between TG:HDL‐C ratio and risk of incident T2D, and the predictive ability of the ratio on top of other diabetes risk factors. Methods Blood biomarkers were determined in 571 T2D cases and 571 controls nested within a prospective, population‐based cohort study, the Singapore Chinese Health Study. Participants were free of diagnosed diabetes, cardiovascular disease, and cancer at the time of blood collection (1999–2004). Incident self‐reported T2D cases were identified at follow‐up interview (2006–10). Controls were matched 1:  1 for age, sex, dialect group, and date of blood collection. Multivariable logistic regression was used to compute the odds ratio (OR) and 95 % confidence interval (CI). Results The ORs (95 % CI) of T2D per 1‐SD increment in TG and TG:  HDL‐C ratio were 1.70 (1.39–2.09) and 1.72 (1.37–2.17), respectively. The relationships were stronger among females than males (Pinteraction = 0.028 and 0.017, respectively), and stronger among lean (