Sleep Disturbances and Neurobehavioral Performance in Juvenile Idiopathic Arthritis

• Published in: Journal of rheumatology 2017-03, Vol.44 (3), p.361-367
• Main Authors: Ward, Teresa M, Beebe, Dean W, Chen, Maida Lynn, Landis, Carol A, Ringold, Sarah, Pike, Ken, Wallace, Carol A
• Format: Article
• Language: English
• Subjects: Arthritis, Juvenile - complications; Arthritis, Juvenile - physiopathology; Arthritis, Juvenile - psychology; Attention - physiology; Child; Female; Humans; Male; Neuropsychological Tests; Polysomnography; Reaction Time - physiology; Sleep - physiology; Sleep Wake Disorders - complications; Sleep Wake Disorders - physiopathology; Sleep Wake Disorders - psychology
• ISSN: 0315-162X; 1499-2752
• DOI: 10.3899/jrheum.160556

To examine the extent of polysomnographic (PSG) sleep disturbances [obstructive apnea hypopnea index (OAHI), number of wake bouts, arousals, periodic limb movements] and the effect of OAHI on neurobehavioral performance in juvenile idiopathic arthritis (JIA) with obstructive sleep apnea (OSA), JIA without OSA, and controls without OSA, adjusting for intelligence quotient (IQ), pain, medications, daytime sleepiness, and wake bouts. Children 6-11 years, 68 with JIA and 67 controls, underwent 1 night of PSG and completed self-reported daytime sleepiness surveys, multiple sleep latency tests for physiological sleepiness, and neurobehavioral performance tests the next day. Compared with JIA and controls without OSA, mean OAHI and arousals were significantly higher in JIA with OSA (p < 0.001, respectively). In comparison with JIA and controls without OSA, mean simple reaction time and sustained attention were significantly slower in JIA with OSA, adjusting for IQ, pain, any medication, daytime sleepiness, and wake bouts. Elevated OAHI is suggestive of obstructive sleep apnea and a comorbidity in JIA that may predispose children with JIA to daytime sleepiness and impaired neurobehavioral performance.