Local image variance of 7 Tesla SWI is a new technique for preoperative characterization of diffusely infiltrating gliomas: correlation with tumour grade and IDH1 mutational status

Objectives To investigate the value of local image variance (LIV) as a new technique for quantification of hypointense microvascular susceptibility-weighted imaging (SWI) structures at 7 Tesla for preoperative glioma characterization. Methods Adult patients with neuroradiologically suspected diffuse...

Full description

Saved in:
Bibliographic Details
Published in:European radiology 2017-04, Vol.27 (4), p.1556-1567
Main Authors: Grabner, Günther, Kiesel, Barbara, Wöhrer, Adelheid, Millesi, Matthias, Wurzer, Aygül, Göd, Sabine, Mallouhi, Ammar, Knosp, Engelbert, Marosi, Christine, Trattnig, Siegfried, Wolfsberger, Stefan, Preusser, Matthias, Widhalm, Georg
Format: Article
Language:English
Subjects:
Adult
Aged
Angiogenesis
Brain cancer
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - pathology
Dehydrogenases
Diagnostic Radiology
Female
Glioma - diagnostic imaging
Glioma - pathology
Humans
Image Interpretation, Computer-Assisted - methods
Image Processing, Computer-Assisted - methods
Imaging
Internal Medicine
Interventional Radiology
Magnetic Resonance
Magnetic Resonance Imaging - methods
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Mutation
Neoplasm Grading
Neuroradiology
Preoperative Care - methods
Prospective Studies
Radiology
Tumors
Ultrasound
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To investigate the value of local image variance (LIV) as a new technique for quantification of hypointense microvascular susceptibility-weighted imaging (SWI) structures at 7 Tesla for preoperative glioma characterization. Methods Adult patients with neuroradiologically suspected diffusely infiltrating gliomas were prospectively recruited and 7 Tesla SWI was performed in addition to standard imaging. After tumour segmentation, quantification of intratumoural SWI hypointensities was conducted by the SWI-LIV technique. Following surgery, the histopathological tumour grade and isocitrate dehydrogenase 1 (IDH1)-R132H mutational status was determined and SWI-LIV values were compared between low-grade gliomas (LGG) and high-grade gliomas (HGG), IDH1-R132H negative and positive tumours, as well as gliomas with significant and non-significant contrast-enhancement (CE) on MRI. Results In 30 patients, 9 LGG and 21 HGG were diagnosed. The calculation of SWI-LIV values was feasible in all tumours. Significantly higher mean SWI-LIV values were found in HGG compared to LGG (92.7 versus 30.8; p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-016-4451-y