Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals

Summary The biological clock, whose function deteriorates with increasing age, determines bodily circadian (i.e. 24h) rhythms, including that of cholesterol metabolism. Dampening of circadian rhythms has been associated with aging and disease. Therefore, we hypothesized that individuals with a famil...

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Bibliographic Details
Published in:Aging cell 2017-04, Vol.16 (2), p.237-243
Main Authors: Berg, Rosa, Noordam, Raymond, Kooijman, Sander, Jansen, Steffy W. M., Akintola, Abimbola A., Slagboom, P. Eline, Pijl, Hanno, Rensen, Patrick C. N., Biermasz, Nienke R., Heemst, Diana
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
aging
biological clock
Biological clocks
Biological Clocks - physiology
Blood cholesterol
Case-Control Studies
Cholesterol
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Circadian rhythm
Circadian Rhythm - physiology
Circadian rhythms
Genetic aspects
Geriatrics
High density lipoprotein
Humans
Lipid metabolism
Lipid Metabolism - physiology
Longevity
Longevity - physiology
Middle Aged
Nonagenarian
Offspring
Original
Physiological aspects
Siblings
Triglycerides
Triglycerides - blood
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Summary:Summary The biological clock, whose function deteriorates with increasing age, determines bodily circadian (i.e. 24h) rhythms, including that of cholesterol metabolism. Dampening of circadian rhythms has been associated with aging and disease. Therefore, we hypothesized that individuals with a familial predisposition for longevity have a higher amplitude circadian serum cholesterol concentration rhythm. The aim of this study was to investigate circadian rhythmicity of serum cholesterol concentrations in offspring of nonagenarian siblings and their partners. Offspring from nonagenarian siblings (n = 19), and their partners as controls (n = 18), were recruited from the Leiden Longevity Study. Participants (mean age 65 years) were studied in a controlled in‐hospital setting over a 24‐h period, receiving three isocaloric meals at 9:00 h, 12:00 h and 18:00 h. Lights were off between 23:00 h and 8:00 h. Serum total cholesterol (TC), HDL cholesterol (HDL‐C), non‐HDL‐C and triglycerides (TG) were determined every 30 min over a 24‐h period. Serum TC concentrations were higher during day than during night in offspring (5.2 vs. 4.7 mm, P 
ISSN:1474-9718
1474-9726
DOI:10.1111/acel.12547