Cerebellar Pathology in Early Onset and Late Onset Essential Tremor

Early onset and late onset essential tremor (ET) cases differ in several respects. Whether they differ with respect to cerebellar pathologic changes remains to be determined. We quantified a broad range of postmortem features (Purkinje cell (PC) counts, PC axonal torpedoes and associated axonal chan...

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Bibliographic Details
Published in:Cerebellum (London, England) England), 2017-04, Vol.16 (2), p.473-482
Main Authors: Kuo, Sheng-Han, Wang, Jie, Tate, William J., Pan, Ming-Kai, Kelly, Geoffrey C., Gutierrez, Jesus, Cortes, Etty P., Vonsattel, Jean-Paul G., Louis, Elan D., Faust, Phyllis L.
Format: Article
Language:English
Subjects:
Age of Onset
Aged, 80 and over
Biomedical and Life Sciences
Biomedicine
Cerebellum - pathology
Essential Tremor - pathology
Female
Humans
Male
Neurobiology
Neurology
Neurosciences
Original Paper
Prospective Studies
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Summary:Early onset and late onset essential tremor (ET) cases differ in several respects. Whether they differ with respect to cerebellar pathologic changes remains to be determined. We quantified a broad range of postmortem features (Purkinje cell (PC) counts, PC axonal torpedoes and associated axonal changes, heterotopic PCs, and hairy basket ratings) in 30 ET cases with age of tremor onset
ISSN:1473-4222
1473-4230
DOI:10.1007/s12311-016-0826-5