Allostatic Load and Reduced Cortical Thickness in Schizophrenia

Highlights • Schizophrenia patients had significantly higher levels of an index of allostatic load compared to healthy controls; this difference partially accounted for lower cortical thickness observed in patients compared to controls. • C-reactive protein was the only component of the allostatic l...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2017-03, Vol.77, p.105-111
Main Authors: Chiappelli, Joshua, Kochunov, Peter, Savransky, Anya, Fisseha, Feven, Wisner, Krista, Du, Xiaoming, Rowland, Laura M, Hong, L. Elliot
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allostasis - physiology
Allostatic load
Biomarkers - blood
Blood Pressure - physiology
Body Mass Index
C-reactive protein
C-Reactive Protein - metabolism
Cerebral Cortex - diagnostic imaging
Cholesterol - blood
Cortical thickness
Endocrinology & Metabolism
Female
Heart Rate - physiology
Humans
Male
Middle Aged
Organ Size - physiology
Psychiatry
Psychotic Disorders - blood
Psychotic Disorders - diagnostic imaging
Psychotic Disorders - physiopathology
Schizophrenia
Schizophrenia - blood
Schizophrenia - diagnostic imaging
Schizophrenia - physiopathology
Stress
Young Adult
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Summary:Highlights • Schizophrenia patients had significantly higher levels of an index of allostatic load compared to healthy controls; this difference partially accounted for lower cortical thickness observed in patients compared to controls. • C-reactive protein was the only component of the allostatic load index inversely correlated with cortical thickness in both patients and controls independently.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.11.021