Correlation between the existence of the palisades of Vogt and limbal epithelial thickness in limbal stem cell deficiency

Background The aims of the study were to investigate limbal epithelial thickness in subjects with limbal stem cell deficiency and to evaluate the correlation between the palisades of Vogt and limbal epithelial thickness. Design Cross‐sectional observational study. Participants Twenty‐four subjects (...

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Bibliographic Details
Published in:Clinical & experimental ophthalmology 2017-04, Vol.45 (3), p.224-231
Main Authors: Le, Qihua, Yang, Yujing, Deng, Sophie X, Xu, Jianjiang
Format: Article
Language:English
Subjects:
Adult
Aged
Anatomic Landmarks
anterior segment optical coherence tomography
Corneal Diseases - diagnosis
Cross-Sectional Studies
Epithelium, Corneal - pathology
Female
Humans
in vivo confocal microscopy
limbal epithelial thickness
limbal stem cell deficiency
Limbus Corneae - pathology
Male
Microscopy, Confocal
Middle Aged
palisades of Vogt
Stem cells
Stem Cells - pathology
Tomography, Optical Coherence
Young Adult
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Summary:Background The aims of the study were to investigate limbal epithelial thickness in subjects with limbal stem cell deficiency and to evaluate the correlation between the palisades of Vogt and limbal epithelial thickness. Design Cross‐sectional observational study. Participants Twenty‐four subjects (39 eyes) with limbal stem cell deficiency and 20 normal controls (20 eyes). Methods Anterior segment optical coherence tomography and laser scanning confocal microscopy were performed to assess each quadrant of the limbus. Main Outcome Measures Limbal epithelial thickness and palisades of Vogt morphology in each quadrant were characterized. The correlation between limbal epithelial thickness and palisades of Vogt was analysed. Results The average limbal epithelial thicknesses in eyes with limbal stem cell deficiency were 19.9%, 23.4%, 13.8% and 13.5% less than normal controls at superior, inferior, nasal and temporal limbus (P = 0.008, 0.006, 0.014 and 0.011, respectively). Limbal epithelial thicknesses within limbal quadrants with palisades of Vogt were similar to those measured in the same quadrants in normal controls, whereas limbal epithelial thicknesses in the superior, inferior, nasal and temporal quadrants without palisades of Vogt were 27.8%, 29.8%, 14.7% and 15.6% less than the limbal epithelial thickness in corresponding regions of normal eyes (superior and inferior: P 
ISSN:1442-6404
1442-9071
DOI:10.1111/ceo.12832