Treatment-associated change in apelin concentration in patients with hypertension and its relationship with left ventricular diastolic function

• Published in: Anatolian journal of cardiology 2017-02, Vol.17 (2), p.125-131
• Main Authors: Baysal, Sadettin Selçuk, Pirat, Bahar, Okyay, Kaan, Bal, Uğur Abbas, Uluçam, Melek Zekiye, Öztuna, Derya, Müderrisoğlu, Haldun
• Format: Article
• Language: English
• Subjects: Amlodipine - therapeutic use; Antihypertensive Agents - therapeutic use; Apelin - blood; Biomarkers - blood; Case-Control Studies; Echocardiography; Female; Humans; Hypertension - blood; Hypertension - drug therapy; Male; Middle Aged; Original Investigation; Prospective Studies; Telmisartan - therapeutic use; Treatment Outcome; Ventricular Dysfunction, Left - blood; Ventricular Dysfunction, Left - diagnostic imaging
• ISSN: 2149-2263; 2149-2271
• DOI: 10.14744/AnatolJCardiol.2016.7035

We examined the change in apelin concentration and its relationship with left ventricular diastolic function in patients treated for hypertension. Ninety treatment-naive patients with newly diagnosed hypertension and 33 age- and sex-matched control subjects were prospectively enrolled. Patients with hypertension were randomized to treatment either with telmisartan 80 mg or amlodipine 10 mg. Apelin concentration was measured and echocardiography was performed at baseline and after 1 month of treatment. The data of 77 patients and 33 controls were analyzed. Mean age, gender, baseline blood pressure, apelin levels, and echocardiographic measurements were similar between the treatment groups (p>0.05 for all). Apelin concentration was significantly lower in patients with hypertension than in controls. There was a significant increase in apelin level after 1 month of treatment in both groups (0.32±0.17 vs. 0.38±0.17 ng/dL in telmisartan group, p=0.009, and 0.27±0.13 vs. 0.34±0.18 ng/dL in amlodipine group, p=0.013). Diastolic function improved significantly in both groups (p