Treatment-associated change in apelin concentration in patients with hypertension and its relationship with left ventricular diastolic function

We examined the change in apelin concentration and its relationship with left ventricular diastolic function in patients treated for hypertension. Ninety treatment-naive patients with newly diagnosed hypertension and 33 age- and sex-matched control subjects were prospectively enrolled. Patients with...

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Published in:Anatolian journal of cardiology 2017-02, Vol.17 (2), p.125-131
Main Authors: Baysal, Sadettin Selçuk, Pirat, Bahar, Okyay, Kaan, Bal, Uğur Abbas, Uluçam, Melek Zekiye, Öztuna, Derya, Müderrisoğlu, Haldun
Format: Article
Language:English
Subjects:
Amlodipine - therapeutic use
Antihypertensive Agents - therapeutic use
Apelin - blood
Biomarkers - blood
Case-Control Studies
Echocardiography
Female
Humans
Hypertension - blood
Hypertension - drug therapy
Male
Middle Aged
Original Investigation
Prospective Studies
Telmisartan - therapeutic use
Treatment Outcome
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - diagnostic imaging
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container_title Anatolian journal of cardiology
container_volume 17
creator Baysal, Sadettin Selçuk
Pirat, Bahar
Okyay, Kaan
Bal, Uğur Abbas
Uluçam, Melek Zekiye
Öztuna, Derya
Müderrisoğlu, Haldun
description We examined the change in apelin concentration and its relationship with left ventricular diastolic function in patients treated for hypertension. Ninety treatment-naive patients with newly diagnosed hypertension and 33 age- and sex-matched control subjects were prospectively enrolled. Patients with hypertension were randomized to treatment either with telmisartan 80 mg or amlodipine 10 mg. Apelin concentration was measured and echocardiography was performed at baseline and after 1 month of treatment. The data of 77 patients and 33 controls were analyzed. Mean age, gender, baseline blood pressure, apelin levels, and echocardiographic measurements were similar between the treatment groups (p>0.05 for all). Apelin concentration was significantly lower in patients with hypertension than in controls. There was a significant increase in apelin level after 1 month of treatment in both groups (0.32±0.17 vs. 0.38±0.17 ng/dL in telmisartan group, p=0.009, and 0.27±0.13 vs. 0.34±0.18 ng/dL in amlodipine group, p=0.013). Diastolic function improved significantly in both groups (p
doi_str_mv 10.14744/AnatolJCardiol.2016.7035
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Ninety treatment-naive patients with newly diagnosed hypertension and 33 age- and sex-matched control subjects were prospectively enrolled. Patients with hypertension were randomized to treatment either with telmisartan 80 mg or amlodipine 10 mg. Apelin concentration was measured and echocardiography was performed at baseline and after 1 month of treatment. The data of 77 patients and 33 controls were analyzed. Mean age, gender, baseline blood pressure, apelin levels, and echocardiographic measurements were similar between the treatment groups (p&gt;0.05 for all). Apelin concentration was significantly lower in patients with hypertension than in controls. There was a significant increase in apelin level after 1 month of treatment in both groups (0.32±0.17 vs. 0.38±0.17 ng/dL in telmisartan group, p=0.009, and 0.27±0.13 vs. 0.34±0.18 ng/dL in amlodipine group, p=0.013). Diastolic function improved significantly in both groups (p&lt;0.05) but was not significantly associated with change in apelin concentration. Apelin concentration increased significantly after 1 month of effective treatment with telmisartan or amlodipine to a similar extent. 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Ninety treatment-naive patients with newly diagnosed hypertension and 33 age- and sex-matched control subjects were prospectively enrolled. Patients with hypertension were randomized to treatment either with telmisartan 80 mg or amlodipine 10 mg. Apelin concentration was measured and echocardiography was performed at baseline and after 1 month of treatment. The data of 77 patients and 33 controls were analyzed. Mean age, gender, baseline blood pressure, apelin levels, and echocardiographic measurements were similar between the treatment groups (p&gt;0.05 for all). Apelin concentration was significantly lower in patients with hypertension than in controls. There was a significant increase in apelin level after 1 month of treatment in both groups (0.32±0.17 vs. 0.38±0.17 ng/dL in telmisartan group, p=0.009, and 0.27±0.13 vs. 0.34±0.18 ng/dL in amlodipine group, p=0.013). 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Diastolic function improved significantly in both groups (p&lt;0.05) but was not significantly associated with change in apelin concentration. Apelin concentration increased significantly after 1 month of effective treatment with telmisartan or amlodipine to a similar extent. Change in apelin concentration was not associated with improvement in diastolic function.</abstract><cop>Turkey</cop><pub>Kare Publishing</pub><pmid>27599667</pmid><doi>10.14744/AnatolJCardiol.2016.7035</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects Amlodipine - therapeutic use
Antihypertensive Agents - therapeutic use
Apelin - blood
Biomarkers - blood
Case-Control Studies
Echocardiography
Female
Humans
Hypertension - blood
Hypertension - drug therapy
Male
Middle Aged
Original Investigation
Prospective Studies
Telmisartan - therapeutic use
Treatment Outcome
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - diagnostic imaging
title Treatment-associated change in apelin concentration in patients with hypertension and its relationship with left ventricular diastolic function
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