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Fluorescence and Magnetic Resonance Dual-Modality Imaging-Guided Photothermal and Photodynamic Dual-Therapy with Magnetic Porphyrin-Metal Organic Framework Nanocomposites
Phototherapy shows some unique advantages in clinical application, such as remote controllability, improved selectivity, and low bio-toxicity, than chemotherapy. In order to improve the safety and therapeutic efficacy, imaging-guided therapy seems particularly important because it integrates visible...
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| Published in: | Scientific reports 2017-03, Vol.7 (1), p.44153, Article 44153 |
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| description | Phototherapy shows some unique advantages in clinical application, such as remote controllability, improved selectivity, and low bio-toxicity, than chemotherapy. In order to improve the safety and therapeutic efficacy, imaging-guided therapy seems particularly important because it integrates visible information to speculate the distribution and metabolism of the probe. Here we prepare biocompatible core-shell nanocomposites for dual-modality imaging-guided photothermal and photodynamic dual-therapy by the
in situ
growth of porphyrin-metal organic framework (PMOF) on Fe
3
O
4
@C core. Fe
3
O
4
@C core was used as
T
2
-weighted magnetic resonance (MR) imaging and photothermal therapy (PTT) agent. The optical properties of porphyrin were well remained in PMOF, and PMOF was therefore selected for photodynamic therapy (PDT) and fluorescence imaging. Fluorescence and MR dual-modality imaging-guided PTT and PDT dual-therapy was confirmed with tumour-bearing mice as model. The high tumour accumulation of Fe
3
O
4
@C@PMOF and controllable light excitation at the tumour site achieved efficient cancer therapy, but low toxicity was observed to the normal tissues. The results demonstrated that Fe
3
O
4
@C@PMOF was a promising dual-imaging guided PTT and PDT dual-therapy platform for tumour diagnosis and treatment with low cytotoxicity and negligible
in vivo
toxicity. |
| doi_str_mv | 10.1038/srep44153 |
| format | article |
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in situ
growth of porphyrin-metal organic framework (PMOF) on Fe
3
O
4
@C core. Fe
3
O
4
@C core was used as
T
2
-weighted magnetic resonance (MR) imaging and photothermal therapy (PTT) agent. The optical properties of porphyrin were well remained in PMOF, and PMOF was therefore selected for photodynamic therapy (PDT) and fluorescence imaging. Fluorescence and MR dual-modality imaging-guided PTT and PDT dual-therapy was confirmed with tumour-bearing mice as model. The high tumour accumulation of Fe
3
O
4
@C@PMOF and controllable light excitation at the tumour site achieved efficient cancer therapy, but low toxicity was observed to the normal tissues. The results demonstrated that Fe
3
O
4
@C@PMOF was a promising dual-imaging guided PTT and PDT dual-therapy platform for tumour diagnosis and treatment with low cytotoxicity and negligible
in vivo
toxicity.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep44153</identifier><identifier>PMID: 28272454</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/57 ; 631/67/1059/602 ; 631/67/2321 ; 639/638/11/942 ; 639/638/298/920 ; 639/638/298/921 ; 64/60 ; Animals ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - therapy ; Cancer ; Chemotherapy ; Contrast Media - chemistry ; Contrast Media - pharmacology ; Cytotoxicity ; Female ; Fluorescence ; Humanities and Social Sciences ; Humans ; Hyperthermia, Induced - methods ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Magnetite Nanoparticles - chemistry ; Magnetite Nanoparticles - therapeutic use ; MCF-7 Cells ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; multidisciplinary ; Nanocomposites ; Optical Imaging - methods ; Optical properties ; Photochemotherapy - methods ; Photodynamic therapy ; Phototherapy ; Science ; Toxicity ; Tumors ; Xenograft Model Antitumor Assays</subject><ispartof>Scientific reports, 2017-03, Vol.7 (1), p.44153, Article 44153</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Mar 2017</rights><rights>Copyright © 2017, The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-bd836d28af219b2b1f5ab7a2ae454a8dfcaecf42f7af92cd7bb87670f147df8f3</citedby><cites>FETCH-LOGICAL-c464t-bd836d28af219b2b1f5ab7a2ae454a8dfcaecf42f7af92cd7bb87670f147df8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1903383627/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1903383627?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25730,27900,27901,36988,44565,53765,53767,75095</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28272454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Li, Yu-Hao</creatorcontrib><creatorcontrib>Chen, Yang</creatorcontrib><creatorcontrib>Wang, Man-Man</creatorcontrib><creatorcontrib>Wang, Xue-Sheng</creatorcontrib><creatorcontrib>Yin, Xue-Bo</creatorcontrib><title>Fluorescence and Magnetic Resonance Dual-Modality Imaging-Guided Photothermal and Photodynamic Dual-Therapy with Magnetic Porphyrin-Metal Organic Framework Nanocomposites</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Phototherapy shows some unique advantages in clinical application, such as remote controllability, improved selectivity, and low bio-toxicity, than chemotherapy. In order to improve the safety and therapeutic efficacy, imaging-guided therapy seems particularly important because it integrates visible information to speculate the distribution and metabolism of the probe. Here we prepare biocompatible core-shell nanocomposites for dual-modality imaging-guided photothermal and photodynamic dual-therapy by the
in situ
growth of porphyrin-metal organic framework (PMOF) on Fe
3
O
4
@C core. Fe
3
O
4
@C core was used as
T
2
-weighted magnetic resonance (MR) imaging and photothermal therapy (PTT) agent. The optical properties of porphyrin were well remained in PMOF, and PMOF was therefore selected for photodynamic therapy (PDT) and fluorescence imaging. Fluorescence and MR dual-modality imaging-guided PTT and PDT dual-therapy was confirmed with tumour-bearing mice as model. The high tumour accumulation of Fe
3
O
4
@C@PMOF and controllable light excitation at the tumour site achieved efficient cancer therapy, but low toxicity was observed to the normal tissues. The results demonstrated that Fe
3
O
4
@C@PMOF was a promising dual-imaging guided PTT and PDT dual-therapy platform for tumour diagnosis and treatment with low cytotoxicity and negligible
in vivo
toxicity.</description><subject>59/57</subject><subject>631/67/1059/602</subject><subject>631/67/2321</subject><subject>639/638/11/942</subject><subject>639/638/298/920</subject><subject>639/638/298/921</subject><subject>64/60</subject><subject>Animals</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - therapy</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Contrast Media - chemistry</subject><subject>Contrast Media - pharmacology</subject><subject>Cytotoxicity</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hyperthermia, Induced - methods</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Magnetite Nanoparticles - therapeutic use</subject><subject>MCF-7 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and Magnetic Resonance Dual-Modality Imaging-Guided Photothermal and Photodynamic Dual-Therapy with Magnetic Porphyrin-Metal Organic Framework Nanocomposites</title><author>Zhang, Hui ; Li, Yu-Hao ; Chen, Yang ; Wang, Man-Man ; Wang, Xue-Sheng ; Yin, Xue-Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-bd836d28af219b2b1f5ab7a2ae454a8dfcaecf42f7af92cd7bb87670f147df8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>59/57</topic><topic>631/67/1059/602</topic><topic>631/67/2321</topic><topic>639/638/11/942</topic><topic>639/638/298/920</topic><topic>639/638/298/921</topic><topic>64/60</topic><topic>Animals</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - therapy</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Contrast Media - chemistry</topic><topic>Contrast Media - pharmacology</topic><topic>Cytotoxicity</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hyperthermia, Induced - methods</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Magnetite Nanoparticles - therapeutic use</topic><topic>MCF-7 Cells</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>multidisciplinary</topic><topic>Nanocomposites</topic><topic>Optical Imaging - methods</topic><topic>Optical properties</topic><topic>Photochemotherapy - methods</topic><topic>Photodynamic therapy</topic><topic>Phototherapy</topic><topic>Science</topic><topic>Toxicity</topic><topic>Tumors</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Li, 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Hui</au><au>Li, Yu-Hao</au><au>Chen, Yang</au><au>Wang, Man-Man</au><au>Wang, Xue-Sheng</au><au>Yin, Xue-Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluorescence and Magnetic Resonance Dual-Modality Imaging-Guided Photothermal and Photodynamic Dual-Therapy with Magnetic Porphyrin-Metal Organic Framework Nanocomposites</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-03-08</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>44153</spage><pages>44153-</pages><artnum>44153</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Phototherapy shows some unique advantages in clinical application, such as remote controllability, improved selectivity, and low bio-toxicity, than chemotherapy. In order to improve the safety and therapeutic efficacy, imaging-guided therapy seems particularly important because it integrates visible information to speculate the distribution and metabolism of the probe. Here we prepare biocompatible core-shell nanocomposites for dual-modality imaging-guided photothermal and photodynamic dual-therapy by the
in situ
growth of porphyrin-metal organic framework (PMOF) on Fe
3
O
4
@C core. Fe
3
O
4
@C core was used as
T
2
-weighted magnetic resonance (MR) imaging and photothermal therapy (PTT) agent. The optical properties of porphyrin were well remained in PMOF, and PMOF was therefore selected for photodynamic therapy (PDT) and fluorescence imaging. Fluorescence and MR dual-modality imaging-guided PTT and PDT dual-therapy was confirmed with tumour-bearing mice as model. The high tumour accumulation of Fe
3
O
4
@C@PMOF and controllable light excitation at the tumour site achieved efficient cancer therapy, but low toxicity was observed to the normal tissues. The results demonstrated that Fe
3
O
4
@C@PMOF was a promising dual-imaging guided PTT and PDT dual-therapy platform for tumour diagnosis and treatment with low cytotoxicity and negligible
in vivo
toxicity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28272454</pmid><doi>10.1038/srep44153</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Scientific reports, 2017-03, Vol.7 (1), p.44153, Article 44153 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5341151 |
| source | Publicly Available Content Database; PubMed Central; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 59/57 631/67/1059/602 631/67/2321 639/638/11/942 639/638/298/920 639/638/298/921 64/60 Animals Breast Neoplasms - diagnostic imaging Breast Neoplasms - therapy Cancer Chemotherapy Contrast Media - chemistry Contrast Media - pharmacology Cytotoxicity Female Fluorescence Humanities and Social Sciences Humans Hyperthermia, Induced - methods Magnetic resonance imaging Magnetic Resonance Imaging - methods Magnetite Nanoparticles - chemistry Magnetite Nanoparticles - therapeutic use MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude multidisciplinary Nanocomposites Optical Imaging - methods Optical properties Photochemotherapy - methods Photodynamic therapy Phototherapy Science Toxicity Tumors Xenograft Model Antitumor Assays |
| title | Fluorescence and Magnetic Resonance Dual-Modality Imaging-Guided Photothermal and Photodynamic Dual-Therapy with Magnetic Porphyrin-Metal Organic Framework Nanocomposites |
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