Dual-energy fluorescent x-ray computed tomography system with a pinhole design: Use of K-edge discontinuity for scatter correction

We propose a pinhole-based fluorescent x-ray computed tomography (p-FXCT) system with a 2-D detector and volumetric beam that can suppress the quality deterioration caused by scatter components. In the corresponding p-FXCT technique, projections are acquired at individual incident energies just abov...

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Bibliographic Details
Published in:Scientific reports 2017-03, Vol.7 (1), p.44143-44143, Article 44143
Main Authors: Sasaya, Tenta, Sunaguchi, Naoki, Thet-Lwin, Thet, Hyodo, Kazuyuki, Zeniya, Tsutomu, Takeda, Tohoru, Yuasa, Tetsuya
Format: Article
Language:English
Subjects:
59
639/166/985
639/766/930/2735
Animals
Computed tomography
Humanities and Social Sciences
Humans
Liver
Medical imaging
Models, Theoretical
multidisciplinary
Optical Imaging
Scattering, Radiation
Science
Tomography, X-Ray Computed
Trace elements
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Description
Summary:We propose a pinhole-based fluorescent x-ray computed tomography (p-FXCT) system with a 2-D detector and volumetric beam that can suppress the quality deterioration caused by scatter components. In the corresponding p-FXCT technique, projections are acquired at individual incident energies just above and below the K-edge of the imaged trace element; then, reconstruction is performed based on the two sets of projections using a maximum likelihood expectation maximization algorithm that incorporates the scatter components. We constructed a p-FXCT imaging system and performed a preliminary experiment using a physical phantom and an I imaging agent. The proposed dual-energy p-FXCT improved the contrast-to-noise ratio by a factor of more than 2.5 compared to that attainable using mono-energetic p-FXCT for a 0.3 mg/ml I solution. We also imaged an excised rat’s liver infused with a Ba contrast agent to demonstrate the feasibility of imaging a biological sample.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep44143