YMO1 suppresses invasion and metastasis by inhibiting RhoC signaling and predicts favorable prognosis in hepatocellular carcinoma

Previous studies have shown that 4.1 proteins, which are deregulated in many cancers, contribute to cell adhesion and motility. Yurt/Mosaic eyes-like 1 (YMO1) is a member of 4.1 protein family but it is unclear whether YMO1 plays a role in tumor invasion. This study aimed to investigate the effects...

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Bibliographic Details
Published in:Oncotarget 2016-08, Vol.7 (34), p.55585-55600
Main Authors: Chang, Rui-Min, Pei, Lei, Fang, Feng, Xu, Jiang-Feng, Yang, Hao, Zuo, Chao-Hui, Zhou, Jian-Hua, Luo, Geng-Qiu, Yang, Lian-Yue
Format: Article
Language:English
Subjects:
Adult
Aged
Animals
Carcinoma, Hepatocellular - pathology
Cell Line, Tumor
Cell Movement
Female
Humans
Liver Neoplasms - pathology
Male
Membrane Proteins - physiology
Mice
Middle Aged
Neoplasm Invasiveness
PAX5 Transcription Factor - physiology
Prognosis
Research Paper
rho-Associated Kinases - physiology
rhoC GTP-Binding Protein - antagonists & inhibitors
rhoC GTP-Binding Protein - physiology
Signal Transduction - physiology
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Summary:Previous studies have shown that 4.1 proteins, which are deregulated in many cancers, contribute to cell adhesion and motility. Yurt/Mosaic eyes-like 1 (YMO1) is a member of 4.1 protein family but it is unclear whether YMO1 plays a role in tumor invasion. This study aimed to investigate the effects of YMO1 on hepatocellular carcinoma (HCC) and attempted to elucidate the underlying molecular mechanisms. YMO1 expression in HCC tissues and its correlation with clinicopathological features and postoperative prognosis was analyzed. The results showed that YMO1 was down-regulated in the highly metastatic HCC cell line and in human tumor tissues. Underexpression of YMO1 indicated poor prognosis of HCC patients. Restoration of YMO1 expression caused a significant decrease in cell migration and invasiveness in vitro. In vivo study showed that YMO1 reduced liver tumor invasion and metastasis in xenograft mice. YMO1 directly inhibited RhoC activation. YMO1 expression in HCC was regulated by PAX5. Analysis of YMO1 expression levels in human HCC patients revealed a significant correlation of YMO1 expression with PAX5 and RhoC. Our findings revealed that YMO1 predicts favorable prognosis and the data suggest that YMO1 suppresses tumor invasion and metastasis by inhibiting RhoC activity.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.10866