Olmesartan-Induced Enteropathy

Olmesartan-induced enteropathy mimics celiac disease clinically and pathologically. As in celiac disease, the pathologic findings are villous atrophy and increased intraepithelial lymphocytes. Clinical presentation of olmesartan-induced enteropathy includes diarrhea, weight loss, and nausea. In cont...

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Bibliographic Details
Published in:Methodist DeBakey cardiovascular journal 2016-10, Vol.12 (4), p.230-232
Main Authors: Adike, Abimbola, Corral, Juan, Rybnicek, David, Sussman, Daniel, Shah, Samir, Quigley, Eamonn
Format: Article
Language:English
Subjects:
Aged
Angiotensin II Type 1 Receptor Blockers - adverse effects
Antihypertensive Agents - adverse effects
Atrophy
Biopsy
Case Report
Celiac Disease - diagnosis
Diagnosis, Differential
Diarrhea - chemically induced
Drug Substitution
Female
Humans
Hypertension - drug therapy
Imidazoles - adverse effects
Intestinal Diseases - chemically induced
Intestinal Diseases - diagnosis
Intestinal Diseases - immunology
Intestinal Mucosa - drug effects
Intestinal Mucosa - immunology
Intestinal Mucosa - pathology
Lymphocytes - drug effects
Lymphocytes - immunology
Microvilli - drug effects
Microvilli - pathology
Predictive Value of Tests
Tetrazoles - adverse effects
Weight Loss - drug effects
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Summary:Olmesartan-induced enteropathy mimics celiac disease clinically and pathologically. As in celiac disease, the pathologic findings are villous atrophy and increased intraepithelial lymphocytes. Clinical presentation of olmesartan-induced enteropathy includes diarrhea, weight loss, and nausea. In contrast to celiac disease, tissue transglutaminase is not elevated and there is no response to a gluten-free diet. Including this entity in the differential diagnosis of sprue-like enteropathy is critical for its early diagnosis since replacing olmesartan with an alternative antihypertensive drug can simplify the diagnostic workup and provide both clinical and histologic improvement.
ISSN:1947-6094
1947-6108
DOI:10.14797/mdcj-12-4-230