Bioactive Glass Fiber-Reinforced PGS Matrix Composites for Cartilage Regeneration

Poly(glycerol sebacate) (PGS) is an elastomeric polymer which is attracting increasing interest for biomedical applications, including cartilage regeneration. However, its limited mechanical properties and possible negative effects of its degradation byproducts restrict PGS for in vivo application....

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Bibliographic Details
Published in:Materials 2017-01, Vol.10 (1), p.83-83
Main Authors: Souza, Marina Trevelin, Tansaz, Samira, Zanotto, Edgar Dutra, Boccaccini, Aldo R
Format: Article
Language:English
Subjects:
Biochemistry
Biocompatibility
Bioglass
Biological activity
Biomedical materials
Body fluids
Cartilage
Degradation
Elastomers
Fiber composites
Glass fiber reinforced plastics
In vitro methods and tests
In vivo methods and tests
Leaching
Mechanical properties
Polymer matrix composites
Polymers
Regeneration
Scaffolds
Tensile strength
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Summary:Poly(glycerol sebacate) (PGS) is an elastomeric polymer which is attracting increasing interest for biomedical applications, including cartilage regeneration. However, its limited mechanical properties and possible negative effects of its degradation byproducts restrict PGS for in vivo application. In this study, a novel PGS-bioactive glass fiber (F18)-reinforced composite was developed and characterized. PGS-based reinforced scaffolds were fabricated via salt leaching and characterized regarding their mechanical properties, degradation, and bioactivity in contact with simulated body fluid. Results indicated that the incorporation of silicate-based bioactive glass fibers could double the composite tensile strength, tailor the polymer degradability, and improve the scaffold bioactivity.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma10010083