Valuation in major depression is intact and stable in a non-learning environment

The clinical diagnosis and symptoms of major depressive disorder (MDD) have been closely associated with impairments in reward processing. In particular, various studies have shown blunted neural and behavioral responses to the experience of reward in depression. However, little is known about wheth...

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Bibliographic Details
Published in:Scientific reports 2017-03, Vol.7 (1), p.44374-44374, Article 44374
Main Authors: Chung, Dongil, Kadlec, Kelly, Aimone, Jason A., McCurry, Katherine, King-Casas, Brooks, Chiu, Pearl H.
Format: Article
Language:English
Subjects:
631/477/2811
692/699/476/1414
Adult
Anhedonia - physiology
Case-Control Studies
Choice Behavior - physiology
Decision making
Decision Making - physiology
Depressive Disorder, Major - physiopathology
Depressive Disorder, Major - psychology
Female
Gambling - psychology
Games, Experimental
Humanities and Social Sciences
Humans
Longitudinal Studies
Male
Mental depression
Middle Aged
multidisciplinary
Reinforcement
Reward
Risk-Taking
Science
Temperature effects
Temperature preferences
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Summary:The clinical diagnosis and symptoms of major depressive disorder (MDD) have been closely associated with impairments in reward processing. In particular, various studies have shown blunted neural and behavioral responses to the experience of reward in depression. However, little is known about whether depression affects individuals’ valuation of potential rewards during decision-making, independent from reward experience. To address this question, we used a gambling task and a model-based analytic approach to measure two types of individual sensitivity to reward values in participants with MDD: ‘risk preference,’ indicating how objective values are subjectively perceived, and ‘inverse temperature,’ determining the degree to which subjective value differences between options influence participants’ choices. On both of these measures of value sensitivity, participants with MDD were comparable to non-psychiatric controls. In addition, both risk preference and inverse temperature were stable over four laboratory visits and comparable between the groups at each visit. Neither valuation measure varied with severity of clinical symptoms in MDD. These data suggest intact and stable value processing in MDD during risky decision-making.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep44374