Noninvasive scoring system for significant inflammation related to chronic hepatitis B

Although a liver stiffness measurement-based model can precisely predict significant intrahepatic inflammation, transient elastography is not commonly available in a primary care center. Additionally, high body mass index and bilirubinemia have notable effects on the accuracy of transient elastograp...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2017-03, Vol.7 (1), p.43752-43752, Article 43752
Main Authors: Hong, Mei-Zhu, Ye, Linglong, Jin, Li-Xin, Ren, Yan-Dan, Yu, Xiao-Fang, Liu, Xiao-Bin, Zhang, Ru-Mian, Fang, Kuangnan, Pan, Jin-Shui
Format: Article
Language:English
Subjects:
13/51
639/705
692/4020/4021/234/2513/1549
82
Antigens
Body mass
Body mass index
Hepatitis
Hepatitis B
Humanities and Social Sciences
Hyperbilirubinemia
Inflammation
Interferon
Liver
multidisciplinary
Science
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although a liver stiffness measurement-based model can precisely predict significant intrahepatic inflammation, transient elastography is not commonly available in a primary care center. Additionally, high body mass index and bilirubinemia have notable effects on the accuracy of transient elastography. The present study aimed to create a noninvasive scoring system for the prediction of intrahepatic inflammatory activity related to chronic hepatitis B, without the aid of transient elastography. A total of 396 patients with chronic hepatitis B were enrolled in the present study. Liver biopsies were performed, liver histology was scored using the Scheuer scoring system, and serum markers and liver function were investigated. Inflammatory activity scoring models were constructed for both hepatitis B envelope antigen (+) and hepatitis B envelope antigen (−) patients. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve were 86.00%, 84.80%, 62.32%, 95.39%, and 0.9219, respectively, in the hepatitis B envelope antigen (+) group and 91.89%, 89.86%, 70.83%, 97.64%, and 0.9691, respectively, in the hepatitis B envelope antigen (−) group. Significant inflammation related to chronic hepatitis B can be predicted with satisfactory accuracy by using our logistic regression-based scoring system.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep43752