Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression

Accumulating evidence shows that hallmarks of cancer include: "genetic and epigenetic alterations leading to inactivation of cancer suppressors, overexpression of oncogenes, deregulation of intracellular signaling cascades, alterations of cancer cell metabolism, failure to undergo cancer cell d...

Full description

Saved in:
Bibliographic Details
Published in:Current genomics 2017-04, Vol.18 (2), p.175-205
Main Author: Ratovitski, Edward A
Format: Article
Language:English
Subjects:
Cancer
Cascades
Cell death
Deactivation
Deoxyribonucleic acid
Deregulation
DNA
DNA damage
DNA repair
Epigenetics
Fungi
Gene expression
Immune response
Immune system
Inactivation
Intracellular signalling
Invasiveness
Marine plants
Mesenchyme
Metabolism
Metastases
Modulators
Molecular modelling
Plants (botany)
Regulators
Suppressors
Transcription
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Accumulating evidence shows that hallmarks of cancer include: "genetic and epigenetic alterations leading to inactivation of cancer suppressors, overexpression of oncogenes, deregulation of intracellular signaling cascades, alterations of cancer cell metabolism, failure to undergo cancer cell death, induction of epithelial to mesenchymal transition, invasiveness, metastasis, deregulation of immune response and changes in cancer microenvironment, which underpin cancer development". Natural compounds as bioactive ingredients isolated from natural sources (plants, fungi, marine life forms) have revolutionized the field of anticancer therapeutics and rapid developments in preclinical studies are encouraging. Natural compounds could affect the epigenetic molecular mechanisms that modulate gene expression, as well as DNA damage and repair mechanisms. The current review will describe the latest achievements in using naturally produced compounds targeting epigenetic regulators and modulators of gene transcription in vitro and in vivo to generate novel anticancer therapeutics.
ISSN:1389-2029
1875-5488
DOI:10.2174/1389202917666160803165229